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New Concepts of Antiviral Therapy
Antiviral drugs are vital - but imperfect - tools for treatment and prevention of viral infections. Undesirable effects, from drug resistant viruses to low oral bioavailability, toxicity and severe side effects limit clinical usefulness. These factors drive demand for improved antiviral strategies. This book offers an up-to-date review of new drugs and targets, novel modes of action, vector-based treatments and even the blocking of defined genes by inhibiting mRNA formation (siRNA). Includes contributions by acknowledged experts; the book will serve as a compendium for R&D and educational professionals, and be of value for students.
Cow's Milk and Allergy
The purpose of this Special Issue “Cow’s Milk and Allergy” is to provide an overview of the association of cow’s milk with allergy. This topic has two quite different faces. On the one hand, we are all aware of the importance of cow’s milk allergy in early life. What is less known is that the consumption of raw, unprocessed milk is associated with a lower incidence of asthma and rhinitis. This Special Issue takes a closer look at all of these aspects of cow’s milk and allergy and focus on the following questions: -Mechanisms of cow’s milk allergy -Epidemiology of cow’s milk allergy -Prevention of cow’s milk allergy -Management and immunotherapy of cow’s milk allergy -Milk processing, baked milk, and cow’s milk allergy -The consumption of raw milk and inhalation allergies
Middleton's Allergy 2-Volume Set
Boasting a worldwide reputation as the leading text in allergy and immunology, Middleton's Allergy continues its steadfast tradition of providing comprehensive coverage of state-of-the-art basic science, as well as authoritative guidance on the clinical concepts of day-to-day diagnosis and management of allergic disorders. Offering timely information that’s suited for clinicians and researchers alike, Middleton’s is a user-friendly and versatile source for the knowledge you need to provide optimal care to your patients! "A valuable source of reference and pre-sifted information ...the editors are to be commending in keeping the book up-to-date and clinically valuable." Reviewed by: Imnun...
Advances in Clinical Chemistry and Laboratory Medicine
This volume comprises the invited plenary lectures and contributed papers presented at the WorldMedLab and the EuroMedLab in Berlin, May 2011 with more than 5.000 participants. The contributions in this volume provide a valuable and wide-ranging overview of current research in Laboratory Medicine and cognate disciplines. Special focus is given to Aging Society (neurological diseases), Tumors, Organ specific dysfunctions and Future of Laboratory Medicine.
Allergic Diseases – From Basic Mechanisms to Comprehensive Management and Prevention
Allergy is the most frequent chronic disease in the 21st century having severe negative effects on health and the economy. The challenge we therefore face in medicine and science incorporates all areas of society – from politics to food industry, from schools to city planning, and many more. This volume informs the reader about continuously ongoing developments in allergy research and their implications for society. The chapter sections cover the immunological mechanisms in allergy on a molecular level, describe the triggers and cures for allergy in detail, entail clinical translation of lab findings on allergens, evaluate diagnostics for allergy markers, and provide solutions for future medical intervention or preventive strategies. Laboratory research, bioinformatics, climate modelling, patient treatment, intervention studies, epigenetics and multiple other disciplines are able to shed new light on this revolutionary field of healthcare.
Autoimmunity, Part C
The incidence of autoimmune diseases is increasing worldwide, and the search for better management of these diseases and even for a cure is being pursued by scientists from many disciplines. Tools from the areas of genetics, neuorscience, cell biology, virology, and infectious disease are being applied to the problem and are yielding useful results. This is the third volume of a series of four on autoimmunity, and findings related to particular organs, organ systems, and diseases are presented. The focus in Part C is on autoimmunity and vessel pathology, the neurologic system, cancer, the GI tract, diabetes, the lung, and the heart. Autoimmunity, Part D completes the group of volumes and als...
Microbial Host-interaction
Most indigenous microbes occur in the intestinal tract, and their interactions with the host are largely unknown. Current understanding of host-microbe interactions links early microbial contact to the origin of disease, a theory that has its roots in the hygiene hypothesis. Modern life style appears to deprive the infant of conditions that provide adequate anti-inflammatory or tolerogenic stimuli upon antigen encounter. Thus, maturational signals from the environment and the diet are insufficient to adequately shape the immune system. This publication deals with the relationship between the gut microbiota as well as altered pattern of early microbial contact and the origin of human disease. New aspects of the original hygiene hypothesis are discussed in relation to disorders spanning from allergy and autoimmunity to obesity.The results presented suggest that all these disorders may be linked to aberrant antigen absorption and immune responses associated with dysfunction of mucosal defense. Researchers, clinicians and students interested in the interaction of the host with indigenous gut bacteria and the consequences for human health will find this publication of utmost interest.
Allergy and Asthma in Modern Society
Allergic diseases and asthma constitute a growing health care problem with a marked socioeconomic impact, especially in industrialized countries. This book summarizes what is currently known about the mechanisms underlying these diseases. Obviously, both environmental and genetic factors influence the development of allergic and asthmatic diseases. Several chapters highlight the role of eosinophils, lymphocytes, and T cells, as well as environmental factors in the development of allergy and asthma. Also discussed are the most recent therapeutic strategies including allergen-specific immunotherapy and anti-IgE treatment as well as the function of histamine as a major mediator of acute inflammatory and immediate hypersensitivity reactions. The interdisciplinary character of this book is documented by articles from various fields such as environmental, molecular, and cellular biology, allergy and dermatology. Representing an excellent collection of state-of-the art reviews, this publication is indispensable for all scientists working in allergy and asthma and for clinicians treating allergic and asthmatic patients.
