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Sleep Disorders
The second part of a two-part work in the Handbook of Clinical Neurology series on sleep disorders.
Genetic Diagnosis of Endocrine Disorders
Genetic Diagnosis of Endocrine Disorders, Second Edition provides users with a comprehensive reference that is organized by endocrine grouping (i.e., thyroid, pancreas, parathyroid, pituitary, adrenal, and reproductive and bone), discussing the genetic and molecular basis for the diagnosis of various disorders. The book emphasizes the practical nature of diagnosing a disease, including which tests should be done for the diagnosis of diabetes mellitus in adults and children, which genes should be evaluated for subjects with congenital hypothyroidism, which genetic tests should be ordered in obese patients or for those with parathyroid carcinoma, and the rationale behind testing for multiple endocrine neoplasias. - Offers a clear presentations of pharmacogenetics and the actual assays used in detecting endocrine diseases - Teaches the essentials of the genetic basis of disease in each major endocrine organ system - Offers expert advice from genetic counselors on how to use genetic information in counseling patients - Includes new chapters on the genetics of lipid disorders and glycogen storage diseases, genetics of hypoglycemia, and whole genome/exome sequencing
Sleep Disorders Part II
Sleep Disorders II covers various aspects of sleep disorders. These include the different classification of sleep disorders, the genetic influences of sleep disorders, abnormality in the sleeping pattern, and the circadian rhythm sleep disorder. A sleep disorder is a medical disorder that affects the sleeping patterns of humans (and sometimes animals). The disruptions in sleep can be caused by different factors, such as teeth grinding, night terrors, and the like. The book also discusses different perspectives on insomnia and hypersomnia. According to the International Classification of Sleep Disorders, insomnia is a sleep that is low in quality or a difficulty in sleeping. On the other hand...
Gamma-Hydroxybutyrate
Gamma-hydroxybutyrate (GHB) has come a long way since early experiments in animals where it was found to induce a sleep-like state and from its use in general anaesthesia in human subjects. It has been found to be a naturally-occurring compound in the brain, a metabolite of GABA, the emerging ubiquitous inhibitory neurotransmitter. This has opened
G Proteins, Receptors, and Disease
More than a collection of review articles, G Proteins, Receptors, and Disease summarizes in depth the state of our knowledge today concerning not only how cells communicate via G-protein-coupled signal transduction processes, but also how defects in these proteins and their receptors can cause serious human disease involving many different organ systems. Written by leading investigators, each chapter describes in detail the structure and function of a particular G protein or receptor, outlines possible mutations, and discusses fully the molecular pathogenesis of associated diseases. Diagnostic and therapeutic implications are also discussed when relevant. In its unique blend of cutting-edge basic science and clinical medicine, G Proteins, Receptors, and Disease offers deep insights into the physiological significance of this key signal transduction pathway, as well as into the molecular basis of diseases ranging from obesity to malignancy. The basic understanding of the complex signal transduction process achieved here provides a firm foundation for future efforts to prevent and cure these diseases.
Molecular Biology and Biotechnology
This is one volume 'library' of information on molecular biology, molecular medicine, and the theory and techniques for understanding, modifying, manipulating, expressing, and synthesizing biological molecules, conformations, and aggregates. The purpose is to assist the expanding number of scientists entering molecular biology research and biotechnology applications from diverse backgrounds, including biology and medicine, as well as physics, chemistry, mathematics, and engineering.
Ligaments and Ligamentoplasties
Despite a substantial amount of literature already accumulated on the subject, our understanding of the structure, function, and biology of the cruciate ligaments has yet to reach the point where we can repair this complicated structure. This volume does not attempt to address every aspect of cruciate ligament replacement, but rather chooses to concentrate on the neurological function of the ligaments. It adopts a pragmatic approach to fatigue testing in more physiological conditions, biomimetic designs, European surgical techniques and new approaches derived from tissue engineering. As such, it is the first volume to sufficiently emphasise the progress that has been made outside of North America and follows more closely the SICOT/SIROT philosophy. The first section provides an overview of the increasing amount of knowledge on natural ligaments, while the second one reviews - using a biomimetical approach - the different concepts and designs of artificial ligaments developed over the last few decades. The final section presents new directions to expand our present understanding and suggests future approaches.
Canadiana
None
Fitzgerald's Clinical Neuroanatomy and Neuroscience
Utilizing clear text and explanatory artwork to make clinical neuroanatomy and neuroscience as accessible as possible, this newly updated edition expertly integrates clinical neuroanatomy with the clinical application of neuroscience. It's widely regarded as the most richly illustrated book available for guidance through this complex subject, making it an ideal reference for both medical students and those in non-medical courses. Complex concepts and subjects are broken down into easily digestible content with clear images and concise, straightforward explanations. Boxes within each chapter contain clinical information assist in distilling key information and applying it to likely real-life ...
Basic and Clinical Neurocardiology
The progression of heart disease is associated with changes in the neurohumoral mechanisms that control cardiac function. The degree to which this neurohumoral remodeling occurs, even before overt signs of cardiac disease become manifest, is important for prognosis. To determine why some patients experience sudden death while others sustain life in the presence of severely compromised cardiac function, the neuronal control of cardiac electrical and mechanical events must be considered. Starting at the level of individual neurons and building upwards, this book describes the synergistic interactions that occur among intrathoracic and CNS feedback loops to permit precise control of regional ca...
