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Rare Rheumatic Diseases of Immunologic Dysregulation
This book is a practical, user-friendly guide for diagnosing and treating patients with rare rheumatic diseases of immunologic dysregulation. Covering uncommon diseases such as IgG4-Related Disease, Castleman’s Disease, and Felty Syndrome, chapters aggregate information from case reports and anecdotal literature to create a single, comprehensive handbook for treating patients. Each chapter provides historical perspective and epidemiology; a literature review (including research trials, translational research, historical and current case reports, and case series); pathogenesis; clinical presentation; laboratory evaluation; imaging; histopathology; treatment; and outcomes. Rare Rheumatic Diseases of Immunologic Dysregulation is an invaluable resource for rheumatologists, rheumatology fellows, and clinical immunologists to better diagnose and treat patients with rare rheumatic diseases.
New Insights into Autoinflammatory Diseases: From Bench to Bedside
Systemic autoinflammatory diseases (SAIDs) are a growing group of rare disorders caused by dysregulation of the innate immune system leading to episodes of organ-specific and systemic inflammation. Autoinflammation as a distinct disease category was first reported in 1999 as a group of monogenic disorders with resultant activation of the inflammasome and cytokine excess, presenting as periodic fever and inflammation in serous membranes. Since this original description, the focus has shifted considerably to the inclusion of complex multifactorial conditions, and more than 30 associated genes have been identified. Disease severity varies from mild to life threatening. Advances in the understanding of the pathogenetic role of interleukin-1, have opened new promising horizons in the treatment of these patients, and significantly altered disease outcome.
Textbook of Autoinflammation
This book, the first complete textbook on this novel field in Medicine, comprehensively covers the clinical presentation, pathogenesis, genetics, and latest management strategies for autoinflammatory disorders as well as the basic science of autoinflammation. Relevant concepts such as how translational science of genetics and immunology relates to the innate immune system and autoinflammation are covered. Descriptions of the monogenic and polygenic/complex diseases that fall under the umbrella of autoinflammatory diseases are provided. Further topics covered include the latest clinical and genetic diagnostic approaches, concepts on the relationship between autoinflammation and autoimmunity/immunodeficiency, the role of autoinflammation in cancer, treatments and management strategies for these diseases, and potential areas of future development. The Textbook of Autoinflammation systematically describes and reviews diagnostic and treatment options for autoinflammatory disorders as well as all aspects of the concept of autoinflammation, and represents a valuable resource for professionals in a variety of disciplines who encounter these patients or who study autoinflammation.
The Romance of Isabel Lady Burton; The Story of Her Life
Reproduction of the original. The publishing house Megali specialises in reproducing historical works in large print to make reading easier for people with impaired vision.
The Dream and the Tomb
This is a comprehensive account of the eight religious wars between the Christian West and the Muslim East that dominated the Middle Ages. Calling themselves "pilgrims of Christ," thousands of Europeans from all stations in life undertook the harsh and bloody quest to reclaim Jerusalem, the Church of the Holy Sepulchre, and Christ's tomb for Christendom. Robert Payne brings to life every step of the Crusaders' thousand-mile journey: the deprivation; the desperate, rapacious, and brutal raids for food and supplies; the epic battles for Antioch, Jerusalem, and Acre; the barbarous treatment of captives; and the quarrelling European princes who vied for power and wealth in the Near East. An epic tale of the glorious and the base, of unshakable faith and unspeakable atrocities, The Dream and the Tomb captures not only the events but the very essence of the Crusades.
The Romance of Isabel Lady Burton
Reproduction of the original: The Romance of Isabel Lady Burton by Isabel Burton, W.H. Wilkins
