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''The scope and depth of this book are excellent....[with] in-depth reviews that will be of benefit to both novice and expert alike....An excellent text worthy of a place on any self-respecting membranologists book shelf and I recommend it highly.'' --- Trends in Biochemical Sciences Molecular Biology of Membrane Transport Disorders comprises the first compilation of papers on the important membrane transporters and ion channels with an emphasis on membrane transport disorders. Internationally recognized leaders in the field provide a thorough understanding of the pathogenesis of clinical conditions that involve derangements in membrane transport processes at the molecular level. This work is a valuable resource for medical and graduate students and researchers in the biomedical sciences, as well as academic physicians in cardiology, nephrology, neurology, and gastroenterology.
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Physiology of the Gastrointestinal Tract, Fifth Edition — winner of a 2013 Highly Commended BMA Medical Book Award for Internal Medicine — covers the study of the mechanical, physical, and biochemical functions of the GI Tract while linking the clinical disease or disorder, bridging the gap between clinical and laboratory medicine. The gastrointestinal system is responsible for the breakdown and absorption of various foods and liquids needed to sustain life. Other diseases and disorders treated by clinicians in this area include: food allergies, constipation, chronic liver disease and cirrhosis, gallstones, gastritis, GERD, hemorrhoids, IBS, lactose intolerance, pancreatic, appendicitis,...
The development of molecular biological techniques and their application in the field has given a new dimension to the area of membrane transport. The combination of biochemical (site-specific reagents), molecular biological (site-directed mutagenesis) and genetic approaches of which this volume gives numerous examples in combination with biophysical techniques as X-ray analysis and NMR will eventually lead to a complete elucidation of the mechanism of action of these transport proteins.Although impossible to give a comprehensive overview of this rapidly expanding field, the expert contributors discuss: pumps involved in primary active transport, carriers which transport metabolites, and channels which allow selective passive transport of particular ions.This volume is ideal for teachers, students and investigators in this field, and will lead to further progress in our understanding of this fascinating field.
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