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The Multi-Messenger Approach to High-Energy Gamma-Ray Sources
This book provides a theoretical and observational overview of the state of the art of gamma-ray astrophysics, and their impact and connection with the physics of cosmic rays and neutrinos. With the aim of shedding new and fresh light on the problem of the nature of the gamma-ray sources, particularly those yet unidentified, this book summarizes contributions to a workshop that continues today.
Proteinases as Drug Targets
This book provides vital information on a class of enzymes that have emerged as key drug targets in a number of human diseases, including HIV/AIDS, Hypertension, Cancer, and Alzheimer's disease. There is a gap in information due to the lack of recent international meetings on this subject and, thus, no recent summaries of current research have emerged. The book contains up-to-date information, especially with the genomics revolution of recent years, and includes new proteomics techniques. The story of this enzyme family also includes the most significant efforts in computer-aided drug discovery and structure-based drug design. With contributions from experts in the field, the book is edited by the previous President of the International Proteolysis Society, whose academic career in the field has spanned 35 years.
Host-Guest Chemistry
with contributions by numerous experts
Molecular Gels
Molecular gels and fibrillar networks – a comprehensive guide to experiment and theory Molecular Gels: Materials with Self-Assembled Fibrillar Networks provides a comprehensive treatise on gelators, especially low molecular-mass gelators (LMOGs), and the properties of their gels. The structures and modes of formation of the self-assembled fibrillar networks (SAFINs) that immobilize the liquid components of the gels are discussed experimentally and theoretically. The spectroscopic, rheological, and structural features of the different classes of LMOGs are also presented. Many examples of the application of the principal analytical techniques for investigation of molecular gels (including SA...
Annual Reports in Medicinal Chemistry
Annual Reports in Medicinal Chemistry
Metabolic Barriers in Cancer and Cancer Therapy
Cancer immunometabolism is an emerging field exploring cellular bioenergetic alterations in both tumor and immune cells and their impact on tumor immune surveillance and therapy resistance. Multiple concepts have emerged including metabolic competition over nutrients and the secretion of (toxic) metabolic byproducts by cancer cells. Moreover, cancer cells are capable of utilizing and shaping their surrounding microenvironment to their favor, e.g. by reprogramming stroma cells to produce essential nutrients or by providing metabolically relevant signaling molecules to foster the accumulation of immunosuppressive cells. Most importantly, this crosstalk within the tumor microenvironment is mostly multi-directional and a better understanding of the complex interactions may pave the way to improved and/or novel therapeutic strategies to overcome those obstacles.
Field-Scale Water and Solute Flux in Soils
This book contains the proceedings of the first workshop held at Monte Verità near Ascona, Switzerland on September 24-29, 1989. The workshop was designed to survey the current understanding of water and solute transport through unsaturated soils under field conditions, and to foster research by discussing some unresolved key issues relative to transport modeling and experimentation in four "Think Tank" groups. The first part of this book consists of the reports prepared by the Think Tank groups, who discussed the following topics: modeling approaches, effective large scale properties, evaluation of filed properties, and the role preferential flow. The second part contains a selection of re...
