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Cell Adhesion and Communication Mediated by the CEA Family
Considers the recent explosion of knowledge about the carcinoembryonic antigen (CEA) family, which resulted from the molecular cloning of family member genes in 1986. Results indicating CEA family members upregulated in cancer could have an instrumental role in malignant transformation and metastasis, while those that are downregulated could have tumor suppressive functions are considered. Reviews, recent results, hypotheses, and clinical applications regarding a gene family that, from its widespread changes in expression in tumors at many sites, should be regarded as a "major player" in human cancer are also discussed. The normal functions such as epithelial and hematopoietic adhesion and signalling molecules are explored, and the possibly unique role of this family in evolution is introduced. This volume will be of interest to researchers in the fields of intercellular adhesion, evolution, and molecular recognition, as well as clinicians interested in the recent knowledge regarding a tumor marker commonly utilised in the clinic, and companies wishing to exploit this cancer-related family for novel commercial applications in the biomedical sphere.
Handbook of Targeted Delivery of Imaging Agents
This is the first time detailed and updated information on the targeted delivery of imaging agents has been collected into a single handbook. This comprehensive volume presents the scientific background together with the latest experimental and clinical data in this fast-growing area. The Handbook of Targeted Delivery of Imaging Agents meets the requirements of the broadest audience including researchers, practitioners, and students. The basic principles of targeted delivery of imaging are presented and discussed together with various imaging agents and different imaging modalities such as gamma-imaging, MR-imaging, and CT, PET, and SPECT imaging. The book consists of eight parts and 39 chap...
Immunology of Malignant Diseases
Over the past 5 years, clinical immunology, as a whole, has advanced more rapidly than over the past 20 years. Many of these advances have been que to monoclonal antibody technology with its ability to identify antigens on tumour cells with a precision never before available. Monoclonal antibodies have the ability to identify subsets of human T-Iymphocytes and aid in diagnosis of both immunodeficiency disorders such as AIDS, or autoimmune diseases, and they can be adapted as drug targeting agents. Additionally, however, major advances have been made in identifying immunomodulating agents, and the last year has seen two such agents, IL-2 and OKT3, made available commercially for such interven...
Energy Research Abstracts
Semiannual, with semiannual and annual indexes. References to all scientific and technical literature coming from DOE, its laboratories, energy centers, and contractors. Includes all works deriving from DOE, other related government-sponsored information, and foreign nonnuclear information. Arranged under 39 categories, e.g., Biomedical sciences, basic studies; Biomedical sciences, applied studies; Health and safety; and Fusion energy. Entry gives bibliographical information and abstract. Corporate, author, subject, report number indexes.
Gastrointestinal Oncology
In 74 chapters, Gastrointestinal Oncology brings together a diverse group of specialists to provide the most authoritative, up-to-date and encyclopedic volume currently available on the subject. The first part of this text introduces a series of concepts and topics taht are important to gastrointestinal malignancies in general. These topics include epidemiologic principles, prevention, screening, familial GI cancers, developmental and molecular biology, pathobiology, general therapeutic principles, emerging therapies, and palliative care. The second part of the book covers each of the specific cancers affecting the human gastrointestinal tract. These chapters are introduced by state of the art discussions outlining our current understanding of the pathobiology and molecular biology relevant to each cancer. Subsequent sections describe the multidisciplinary management of specific clinical situations. By organizing the treatment-related chapters around clinical scenarios, the reader will readily find the information necessary to effectively manage the complex clinical situations encountered by patients with gastrointestinal malignancies.
