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Skin Therapy
A collection of articles examining recent developements in skin therapy, and discussing issues of importance for the effective management of patients.
Serotonin Receptors and their Ligands
An international group of authors have produced an overview of the progress made in the medicinal chemistry of compounds (selectively) acting at serotonin receptors or serotonin transporters either as agonists, partial agonists or antagonists.Structure - affinity relationships and structure - activity relationships of agonists, partial agonists, and antagonists of 5-HT receptors and uptake sites, are discussed. Structure, sequence homology and the effect of site-directed mutations of 5-HT receptors and the reuptake site on the binding of ligands show the tremendous impact of molecular biology on medicinal chemistry research. Also discussed is the pharmacology and (potential) clinical applica...
New Insights in Anaphylaxis
Anaphylaxis has usually been studied and understood from an immunological view and the main lethal effects involve the cardio-vascular system. Despite exhaustive efforts exerted in this area of research, much more investigation is needed to mitigate, recognize or prevent this disease. The scope of this Research Topic is to present and discuss the current knowledge of anaphylaxis, from the clinic to the underlying molecular mechanisms. We are thankful to the medical doctors, researchers, and colleagues who have contributed to this issue, as it would not have been possible without their highly valuable expertise in allergy and anaphylaxis research.
