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Beyond the Farm
During the first half-century of American independence, a fundamental change in the meaning and morality of ambition emerged in American culture. Long stigmatized as a dangerous passion that led people to pursue fame at the expense of duty, ambition also raised concerns among American Revolutionaries who espoused self-sacrifice. After the ratification of the U.S. Constitution and the creation of the federal republic in 1789, however, a new ethos of nation-making took hold in which ambition, properly cultivated, could rescue talent and virtue from the parochial needs of the family farm. Rather than an apology for an emerging market culture of material desire and commercial dealing, ambition b...
The Sepsis Text
This textbook is written at the dawn of a new era in the management of sepsis. Recent achievements in the clinical management of septic shock are the culmination of decades of basic and applied research by innovative researchers and clinical investigators worldwide. The contributing authors to this book have spearheaded much of this research and the Editors have endeavored to create a textbook that is comprehensive in nature while maintaining a specific focus upon the multitude of work that constitutes the spectrum of sepsis research including: pathophysiology; monitoring systems; general support; microbial aspects; complications; and anti-sepsis therapies.
Avenging the People
"With the passionate support of most voters and their families, Andrew Jackson broke through the protocols of the Founding generation, defying constitutional and international norms in the name of the "sovereign people." And yet Jackson's career was no less about limiting that sovereignty, imposing one kind of law over Americans so that they could inflict his sort of "justice" on non-Americans. Jackson made his name along the Carolina and Tennessee frontiers by representing merchants and creditors and serving governors and judges. At times that meant ejecting white squatters from native lands and returning blacks slaves to native planters. Jackson performed such duties in the name of federal...
Opal Plumstead
‘Opal – plain-talking, fiery Opal, who fights her fellow workers, has taken over the entire design department and is now a mini-suffragette? Opal Plumstead might be plain, but she has always been fiercely intelligent. Yet her scholarship and dreams of university are snatched away when her father is sent to prison, and fourteen-year-old Opal must start work at the Fairy Glen sweet factory to support her family. She struggles to get along with her other workers, who think she’s snobby and stuck up. But Opal idolises Mrs Roberts, the factory’s beautiful, dignified owner. The best thing about Mrs Roberts? She’s a suffragette! Opal’s world is opened to Mrs Pankhurst, and the fight to give women the right to vote. And when Opal meets Morgan, Mrs Roberts’ handsome son , and heir to Fairy Glen- she believes she’s found her soulmate. But the First World War is about to begin, and will change Opal's life for ever. A brilliantly gripping wartime story from the bestselling, award-winning Jacqueline Wilson.
Handbook of Sepsis
This practically oriented book provides an up-to-date overview of all significant aspects of the pathogenesis of sepsis and its management, including within the intensive care unit. Readers will find information on the involvement of the coagulation and endocrine systems during sepsis and on the use of biomarkers to diagnose sepsis and allow early intervention. International clinical practice guidelines for the management of sepsis are presented, and individual chapters focus on aspects such as fluid resuscitation, vasopressor therapy, response to multiorgan failure, antimicrobial therapy, and adjunctive immunotherapy. The closing section looks forward to the coming decade, discussing novel trial designs, sepsis in low- and middle-income countries, and emerging management approaches. The book is internatio nal in scope, with contributions from leading experts worldwide. It will be of value to residents and professionals/practitioners in the fields of infectious diseases and internal medicine, as well as to GPs and medical students.
Endotoxemia and Endotoxin Shock
The presence of endotoxin in the bloodstream is the consequence of an immunological response triggered by bacterial invasion of the host. This condition leads to altered cardiovascular function, lung dysfunction and acute kidney injury. Removing as much as possible of the circulating endotoxin is therefore imperative to mitigate its biological and clinical effects at the cellular, tissue and organ levels. The publication at hand summarizes the basic mechanisms, rationale and clinical results of a new therapeutic approach that promises to attain this goal: It consists of a specific hemoperfusion process that utilizes cartridges with immobilized polymixin B in an extracorporeal circuit.Containing contributions by renowned researchers, this book represents as a milestone in the field of extracorporeal therapies in sepsis. It will be a valuable reference work for both basic scientists and clinical professionals who want to keep abreast of current developments.
Meningococcal Disease
Meningococcal septicemia and meningitis continue to be important causes of devastating illness, death, and long-term disability in both developed and resource-poor countries of the world. Few diseases have attracted as much public attention, or are as feared by parents and family members, as well as the medical staff who have to care for affected patients. The unexpected and unp- dictable occurrence of the disease in previously healthy children and young adults, its rapid progression, and the frequent occurrence of purpura fulminans with the resulting gangrene of limbs and digits and the requirement for mutilating s- gery, have all heightened both public and medical interest in the disease. ...
Intensive Care Medicine
This reference book compiles the most recent developments in experimental and clinical research and practice in one comprehensive edition. The chapters are written by well recognized experts in the field of intensive care and emergency medicine. It is addressed to everyone involved in internal medicine, anesthesia, surgery, pediatrics, intensive care and emergency medicine.
Gene Therapy and Cancer Research Focus
Genes, which are carried on chromosomes, are the basic physical and functional units of heredity. Genes are specific sequences of bases that encode instructions on how to make proteins. Although genes get a lot of attention, it's the proteins that perform most life functions and even make up the majority of cellular structures. When genes are altered so that the encoded proteins are unable to carry out their normal functions, genetic disorders can result. Gene therapy is an experimental treatment that involves introducing genetic material into a person's cells to fight disease. Gene therapy is being studied in clinical trials for many different types of cancer and for numerous other diseases. The volume presents significant new research results in this promising field.
