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Avenging the People
"With the passionate support of most voters and their families, Andrew Jackson broke through the protocols of the Founding generation, defying constitutional and international norms in the name of the "sovereign people." And yet Jackson's career was no less about limiting that sovereignty, imposing one kind of law over Americans so that they could inflict his sort of "justice" on non-Americans. Jackson made his name along the Carolina and Tennessee frontiers by representing merchants and creditors and serving governors and judges. At times that meant ejecting white squatters from native lands and returning blacks slaves to native planters. Jackson performed such duties in the name of federal...
Beyond the Farm
During the first half-century of American independence, a fundamental change in the meaning and morality of ambition emerged. Beyond the Farm blends biography, social history, and cultural history to describe and explain that change.
Opal Plumstead
‘Opal – plain-talking, fiery Opal, who fights her fellow workers, has taken over the entire design department and is now a mini-suffragette? Opal Plumstead might be plain, but she has always been fiercely intelligent. Yet her scholarship and dreams of university are snatched away when her father is sent to prison, and fourteen-year-old Opal must start work at the Fairy Glen sweet factory to support her family. She struggles to get along with her other workers, who think she’s snobby and stuck up. But Opal idolises Mrs Roberts, the factory’s beautiful, dignified owner. The best thing about Mrs Roberts? She’s a suffragette! Opal’s world is opened to Mrs Pankhurst, and the fight to give women the right to vote. And when Opal meets Morgan, Mrs Roberts’ handsome son , and heir to Fairy Glen- she believes she’s found her soulmate. But the First World War is about to begin, and will change Opal's life for ever. A brilliantly gripping wartime story from the bestselling, award-winning Jacqueline Wilson.
Gene Therapy and Cancer Research Focus
Genes, which are carried on chromosomes, are the basic physical and functional units of heredity. Genes are specific sequences of bases that encode instructions on how to make proteins. Although genes get a lot of attention, it's the proteins that perform most life functions and even make up the majority of cellular structures. When genes are altered so that the encoded proteins are unable to carry out their normal functions, genetic disorders can result. Gene therapy is an experimental treatment that involves introducing genetic material into a person's cells to fight disease. Gene therapy is being studied in clinical trials for many different types of cancer and for numerous other diseases. The volume presents significant new research results in this promising field.
Meningococcal Disease
Meningococcal septicemia and meningitis continue to be important causes of devastating illness, death, and long-term disability in both developed and resource-poor countries of the world. Few diseases have attracted as much public attention, or are as feared by parents and family members, as well as the medical staff who have to care for affected patients. The unexpected and unp- dictable occurrence of the disease in previously healthy children and young adults, its rapid progression, and the frequent occurrence of purpura fulminans with the resulting gangrene of limbs and digits and the requirement for mutilating s- gery, have all heightened both public and medical interest in the disease. ...
Cytokines in Severe Sepsis and Septic Shock
This book deals with the central role of cytokines in the generalized inflammatory response of the host as the consequence of severe infection/endotoxin action. International specialists cover several aspects in 20 chapters starting with the agents responsible (endotoxin, superantigens) and recognition during cytokine induction. Further chapters deal with the signal transduction cascade, its modulation due to sex or genetic polymorphism, and the possibilities and problems in detection (including surrogate markers). Major targets of actions are covered in the chapters on coagulation-/fibrinolysis, adherence molecules, vasoactive factors, apoptosis and metabolism. As not all actions of cytokines are beneficial, several chapters deal with the prevention of induction, modulation of the cytokine generation or scavenging cytokines including gene therapy approaches. Models are necessary for obtaining pathophysiological information and for testing therapeutic approaches, and thus all chapters deal with experimental models as well as clinical trials. The reasons why these have failed so far are the subject of the final chapter.
Intensive Care Medicine
This reference book compiles the most recent developments in experimental and clinical research and practice in one comprehensive edition. The chapters are written by well recognized experts in the field of intensive care and emergency medicine. It is addressed to everyone involved in internal medicine, anesthesia, surgery, pediatrics, intensive care and emergency medicine.
Endotoxemia and Endotoxin Shock
The presence of endotoxin in the bloodstream is the consequence of an immunological response triggered by bacterial invasion of the host. This condition leads to altered cardiovascular function, lung dysfunction and acute kidney injury. Removing as much as possible of the circulating endotoxin is therefore imperative to mitigate its biological and clinical effects at the cellular, tissue and organ levels. The publication at hand summarizes the basic mechanisms, rationale and clinical results of a new therapeutic approach that promises to attain this goal: It consists of a specific hemoperfusion process that utilizes cartridges with immobilized polymixin B in an extracorporeal circuit.Containing contributions by renowned researchers, this book represents as a milestone in the field of extracorporeal therapies in sepsis. It will be a valuable reference work for both basic scientists and clinical professionals who want to keep abreast of current developments.
