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Contemporary Targeted Therapies in Rheumatology
Targeted therapies of rheumatic diseases have become a reality and have completely changed patient care as well as patient expectations. Initial success with therapies aimed at blocking TNF and IL-1 has stimulated the development of additional targeted approaches focused on other cytokines as well as specific cells and pathways involved in the path
Intelligent Virtual Agents
Welcome to the proceedings of the 9th International Conference on Intelligent Virtual Agents, held September 14–16, 2009 in Amsterdam, The Netherlands. Intelligent virtual agents (IVAs) are interactive characters that exhibit hum- like qualities and communicate with humans or with each other using natural human modalities such as speech and gesture. They are capable of real-time perception, cognition and action, allowing them to participate in a dynamic physical and social environment. IVA is an interdisciplinary annual conference and the main forum for p- senting research on modeling, developing and evaluating IVAs with a focus on communicative abilities and social behavior. The developme...
Christian-Muslim Relations. A Bibliographical History. Volume 2 (900-1050)
Christian-Muslim Relations, a Bibliographical History 2 (CMR2) is the second part of a general history of relations between the faiths. Covering the period from 900 to 1050, it comprises a series of introductory essays, together with the main body of more than one hundred detailed entries on all the works by Christians and Muslims about and against one another that are known from this period. These entries provide biographical details of the authors where known, descriptions and assessments of the works themselves, and complete accounts of manuscripts, editions, translations and studies. The result of collaboration between leading scholars in the field, CMR2 is an indispensable basis for research in all elements of the history of Christian-Muslim relations.
Christian-Muslim Relations. A Bibliographical History. Volume 3 (1050-1200)
Christian-Muslim Relations, a Bibliographical History 3 (CMR3) is the third part of a general history of relations between the faiths. Covering the period from 1050 to 1200, it comprises a series of introductory essays, together with the main body of more than one hundred detailed entries on all the works by Christians and Muslims about and against one another that are known from this period. These entries provide biographical details of the authors where known, descriptions and assessments of the works themselves, and complete accounts of manuscripts, editions, translations and studies. The result of collaboration between leading scholars in the field, CMR3 is an indispensable basis for research in all elements of the history of Christian-Muslim relations.
The Plant Viruses
This fifth volume in the series The Plant Viruses, dealing with viruses with bipartite genomes, completes the coverage of viruses with isometric parti cles and genomes consisting of single-stranded, positive-sense RNA: viruses that have tripartite and monopartite genomes of this kind were dealt with in Volumes 1 and 3, respectively. How close are the affinities among the viruses within the groupings distinguished in this way? All those with tripartite genomes are considered to be sufficiently closely related to be included in the family Bromoviridae, whereas the monopartite-genome viruses covered in Volume 3 clearly are a much more diverse collection. Affinities among the viruses with bipart...
Cell-Cell Channels
he biological sciences are dominated by the idea that cells are the functionally autonomous, physically separated, discrete units of life. TThis concept was propounded in the 19th century by discoveries of the cellular structuring of both plants and animals. Moreover, the ap parent autonomy of unicellular eukaryotes, as well as the cellular basis of the mammalian brain (an organ whose anatomy for a long while defied attempts to validate the idea of the cellular nature of its neurons), seemed to provide the final conclusive evidence for the completeness of *cell theory', a theory which has persisted in an almost dogmatic form up to the present day. However, it is very obvious that there are n...
Membrane Trafficking in Viral Replication
Viruses are major pathogens in humans, and in the organisms with which we share this planet. The massive health and economic burden these agents impose has spurred a huge research effort to understand their most intimate details. One outcome of this effort has been the production, in many but certainly not all cases, of effective vaccines and therapies. - other consequence has been the realization that we can exploit viruses and put them to work on our behalf. Viruses are still seen to have the most - tential as vehicles for gene delivery and other therapeutic applications. However, their ability to exploit cellular functions to their own ends makes viruses not only highly effective pathogens but also exquisite experimental tools. Work with viruses underpins much of our current understanding of molecular cell biology and related fields. For membrane traffic in parti- lar, viruses have been crucial in providing insights into key cellular fu- tions and the molecular mechanisms underlying these events.
Christian-Muslim Relations. A Bibliographical History. Volume 5 (1350-1500)
Christian-Muslim Relations, a Bibliographical History 5 (CMR 5), covering the period 1350-1500, is a continuing volume in a general history of relations between the two faiths from the seventh century to 1900. It comprises a series of introductory essays and also the main body of detailed entries which treat all the works, surviving or lost, that have been recorded. These entries provide biographical details of the authors, descriptions and assessments of the works themselves, and complete accounts of manuscripts, editions, translations and studies. The result of collaboration between numerous leading scholars, CMR 5, along with the other volumes in this series, is intended as an indispensable tool for research in Christian-Muslim relations.
Christian-Muslim Relations
Christian-Muslim Relations, a Bibliographical History 1 (CMR1) is the first part of a general history of relations between the faiths from the seventh century to the present. It covers the period from 600 to 1500, when encounters took place through the extended Mediterranean basin and are recorded in Syriac, Arabic, Greek, Latin and other languages. It comprises introductory essays on the treatment of Christians in the Qur'an, Qur'an commentaries, biographies of the Prophet, Hadith and Sunni law, and of Muslims in canon law, and the main body of more than two hundred detailed entries on all the works recorded, whether surviving or lost. These entries provide biographical details of the authors where known, descriptions and assessments of the works themselves, and complete accounts of manuscripts, editions, translations and studies. The result of collaboration between leading scholars, CMR1 is intended as a basic tool for research in Christian-Muslim relations.
