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Advances in Cancer Research
There has been major growth in understanding immune suppression mechanisms and its relationship to cancer progression and therapy. This book highlights emerging new principles of immune suppression that drive cancer, and it offers radically new ideas about how therapy can be improved by attacking these principles. Following work that firmly establishes immune escape as an essential trait of cancer, recent studies have now defined specific mechanisms of tumor immune suppression. It also demonstrates how attacking tumors with molecular targeted therapeutics or traditional chemotherapeutic drugs can produce potent anti-tumor effects in preclinical models. This book provides basic, translational...
This book examines cross-chain control centers (4C), an ambitious concept in supply chain management and logistics that is intended to foster collaboration between different supply chains to increase efficiency. It provides an overview of the main results, insights, and other developments in the academic field of horizontal collaboration. Furthermore, it gives recommendations to governments, commercial companies, and academia on how to proceed with horizontal logistics collaboration in the years to come. To link research with practice, the book takes the Dutch project on cross-chain collaboration centers (4Cs) and identifies a typology of existing patterns for horizontal collaboration in supply chains. Finally, the book zooms in on the Netherlands as a case-study of intense public-private partnerships to develop 4C as a mature logistics value proposition. It provides an overview of the accomplishments in the government supported 4C projects and offers a critical reflection of why some more ambitious and structural solutions have not found solid ground yet. The book is of value to researchers and professionals in the supply chain domain.
This book systematically reviews and discusses recent studies and articles on the immunology of female genital tract tissue. The scope is broad, encompassing innate immune responses, adaptive (humoral and cell-mediated) immunity, the immunology of menstruation, the immunology of viral and bacterial infections, the immunology of normal and abnormal pregnancy, and immunological infertility. Throughout, tables and illustrations are judiciously used to facilitate understanding. Immunology of the Female Genital Tract will serve as an invaluable source of up-to-date information for all with an interest in this subject.
Rubin and Damjanov's latest volume of Pathology Reviews highlights the latest progress in the interface of biology and disease. Forefront techniques and experimental models that were once considered exotic or esoteric, are explored here in the context of understanding more fully the processes involved in human disease. Topics include: regulation of liver growth • contractile cells in lungs • mineral formation in bone • folate metabolism • the "riddle of the mast cell" • HLA antigens • interleukin 6 • IgA nephropathy • Goodpasture syndrome • anti-basement membrane glomerulonephropathy • molecular mechanisms of oncogenesis • molecular diagnosis of cancer • inhibition of intercellular communication in carcinogenesis • DNA repair and its pathogenetic implications • human and rat mammary tumorigenesis. Pathology Reviews • 1990 is essential reading for everyone concerned with the mechanisms of disease.
This book is meant to provide a complete overview of the research of HPV and its connection to cervical cancer.
Emerging and re-emerging pathogens pose several challenges to diagnosis, treatment, and public health surveillance, primarily because pathogen identification is a difficult and time-consuming process due to the “novel” nature of the agent. Proper identification requires a wide array of techniques, but the significance of these diagnostics is anticipated to increase with advances in newer molecular and nanobiotechnological interventions and health information technology. Human Emerging and Re-emerging Infections covers the epidemiology, pathogenesis, diagnostics, clinical features, and public health risks posed by new viral and microbial infections. The book includes detailed coverage on ...