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Mechanisms of Neural Circuit Formation
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The world according to zebrafish: How neural circuits generate behaviour
Understanding how the brain functions is one of the most ambitious current scientific goals. This challenge will only be accomplish by a multidisciplinary approach involving genetics, molecular biology, optics, ethology, neurobiology and mathematics and using tractable model systems. The zebrafish larva is a transparent genetically tractable small vertebrate, ideal for the combination state-of-the- art imaging techniques (e.g. two-photon scanning microscopy, single-plane illumination microscopy, spatial light modulator microscopy and lightfield microscopy), bioluminiscence and optogenetics to monitor and manipulate neuronal activity from single specific neurons up to the entire brain, in an intact behaving organism. Furthermore, the zebrafish model offers large and increasing collection of mutant and transgenic lines modelling human brain diseases. With these advantages in hand, the zebrafish larva became in the recent years, a novel animal model to study neuronal circuits and behaviour, taking us closer than ever before to understand how the brain controls behaviour.
The Journal of Cell Biology
No. 2, pt. 2 of November issue each year from v. 19 (1963)-47 (1970) and v. 55 (1972)- contain the Abstracts of papers presented at the Annual Meeting of the American Society for Cell Biology, 3d (1963)-10th (1970) and 12th (1972)-
Science
A weekly record of scientific progress.
Scientific Report
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Committee documents
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The Cadherin Superfamily
This book presents an overview of the entire field of cadherin research and provides the current basic concept of cadherins. Cadherins have been widely accepted as key regulators of animal development and physiological functions, and it also has become clear that they play essential roles in various human diseases. With contributions by leading scientists, the book covers various aspects of the cadherin superfamily including the history of cadherin research, basic properties of classical cadherins as well as non-classical cadherins, cadherin-associated proteins, and the roles of cadherins in health and diseases. In addition, the book presents some contradictory results and important unanswered questions, and the authors propose their working hypotheses or future directions, to inspire future studies. This volume enables graduate students and young researchers to learn the basics and gain a comprehensive image of the cadherin superfamily, and experts in the field will easily find various topics of interest in relevant areas of study. Additionally, a list of cadherin-related diseases is included for quick reference to cadherins in human diseases.
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