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Exploiting Chemical Diversity for Drug Discovery
Conceptual and technological advances in chemistry and biology have transformed the drug discovery process. Evolutionary pressure among the diverse scientific and engineering disciplines that contribute to the identification of biologically active compounds has resulted in synergistic improvements at every step in the process. Exploiting Chemical Diversity for Drug Discovery encompasses the many components of this transformation and presents the current state-of-the-art of this critical endeavour. From the theoretical and operational considerations in generating a collection of compounds to screen, to the design and implementation of high-capacity and high-quality assays that provide the mos...
Molecular Chaperones in Health and Disease
Molecular chaperones are involved in a wide variety of essential cellular processes in living cells. A subset of molecular chaperones have been initially described as heat shock proteins protecting cells from stress damage by keeping cellular proteins in a folding competent state and preventing them from irreversible aggregation. Later it became obvious that molecular chaperones are also expressed constitutively in the cell and are involved in complex processes such as protein synthesis, intracellular protein transport, post-translational modification and secretion of proteins as well as receptor signalling. Hence, it is not surprising that molecular chaperones are implicated in the pathogenesis of many relevant diseases and could be regarded as potential pharmacological targets. Starting with the analysis of the mode of action of chaperones at the molecular, cellular and organismic level, this book will then describe specific aspects where modulation of chaperone action could be of pharmacological and therapeutic interest.
Lectures on Quantum Information
Quantum Information Processing is a young and rapidly growing field of research at the intersection of physics, mathematics, and computer science. Its ultimate goal is to harness quantum physics to conceive -- and ultimately build -- "quantum" computers that would dramatically overtake the capabilities of today's "classical" computers. One example of the power of a quantum computer is its ability to efficiently find the prime factors of a larger integer, thus shaking the supposedly secure foundations of standard encryption schemes. This comprehensive textbook on the rapidly advancing field introduces readers to the fundamental concepts of information theory and quantum entanglement, taking i...
Flavour Science
The aroma characteristics of aged smoke and its residue have not been characterized. In this study, “ashtray aroma” was analyzed using gas chromatography olfactometry (GC-O) combined with aroma extract dilution analysis (AEDA) of ashtray solvent extracts and static headspace analysis of ashtrays. A total of 33 odor-active regions were detected in the headspace and a total of 56 odor-active regions with flavor dilution (FD) factors≥32 were detected in the solvent extract. In addition, the ashtray aroma was assessed descriptively by a trained volunteer panel.
Hadron Physics
Straddling the traditional disciplines of nuclear and particle physics, hadron physics is a vital and extremely active research area, as evidenced by a 2004 Nobel prize and new research facilities, such as that scheduled to open at CERN. Scientifically it is of vital importance in extrapolating our knowledge of quark-gluon physics at the sub-nucleon level to provide a wider perspective of strongly interacting hadrons, which make up the vast bulk of known matter in the Universe. Through detailed, pedagogical chapters contributed by key international experts, Hadron Physics maps out our contemporary knowledge of the subject. It covers both the theoretical and experimental aspects of hadron structure and properties along with a wide range of specific research topics, results, and applications. Providing a full picture of activity in the field, the book highlights three particular areas of current research: computational lattice hadron physics, the structure and dynamics of hadrons, and generalized parton distributions. It provides a solid introduction, includes background theory, and presents the current state of understanding of the subject.
Flavour Science
The flavor of a food is often the most desirable quality characteristic for the consumer, yet the understanding of flavour is a fascinatingly complicated subject, which calls for interdisciplinary research efforts. This latest volume presents the proceedings of the 11th Weurman Flavour Research Symposium and describes the most recent and original research advances related to the flavour of foods and beverages with contributions of experts from 25 countries world-wide.* Efficiently summarises the current front line research within food flavor* Highlights the modern approaches to flavor production using biotechnology, enzymes and gene-technology * The dynamic effects of manipulation of food in the mouth during consumption influencing the release of flavour compounds is discussed in detail
