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NETosis 2: The Excitement Continues
NETosis, a form of cell death that manifests by the release of decondensed chromatin to the extracellular space, provides valuable insights into mechanisms and consequences of cellular demise. Because extracellular chromatin can immobilize microbes, the extended nucleohistone network was called a neutrophil extracellular trap (NET), and the process of chromatin release was proposed to serve an innate immune defense function. Extracellular chromatin NETs were initially observed in studies of neutrophils and are most prominent in these types of granulocytes. Subsequent studies showed that other granulocytes and, in a limited way, other cells of the innate immune response may also release nucle...
Neutrophil Extracellular Traps
Neutrophils regulate immune responses during homeostasis as well as disease pathogenesis. Especially, the neutrophils extracellular traps largely contribute to necroinflammation. This book highlights the role of neutrophils and neutrophils extracellular traps in various sterile and non-sterile, acute and chronic inflammatory conditions affecting both human and animal health.
Autoantibodies
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The Current
"A first-rate thriller . . . Past and present merge in The Current, Tim Johnston's atmospheric, exquisitely suspenseful novel of two murders separated by ten years." —The Washington Post “Gripping . . . Johnston’s masterful novel is worth lingering over—it soars above the constraints of a traditional thriller and pulls you deep into the secrets of a grief-stricken town.” —People Tim Johnston, whose breakout debut Descent was called “astonishing,” “dazzling,” and “unforgettable” by critics, returns with The Current, a tour de force about the indelible impact of a crime on the lives of innocent people. In the dead of winter, outside a small Minnesota town, state trooper...
Narrowing the Channel
While large, multinational corporations have supported the removal of tariffs, behind the scenes these firms have fought for protection in the form of product regulations, including testing, labeling, and registration requirements. Unlike tariffs, these regulations can raise fixed costs, excluding smaller firms from the market and shifting profits toward global giants. Narrowing the Channel demonstrates that globalization and globalized firms can paradoxically hinder rather than foster economic cooperation as larger firms seek to protect their markets through often unnecessarily strict product regulations. To illustrate the problem of regulatory protectionism, Robert Gulotty offers an in-dep...
The New Land
Papers originally presented at a workshop held at the University of Calgary on Aug. 1-5, 1977.
