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Physico-chemical and Computational Approaches to Drug Discovery
This title covers a wide range of topics relevant to the development of drugs. It provides a comprehensive description of the major methodological strategies available for rational drug discovery.
Life Hurts at El Hormigón
In every city in the world there are dens where the light does not enter out of shame, like El Homgon. There, darkness envelops the trickery of the customers, the hands that grope the bodies and the filth that accumulates in the corners. A few years ago, my friend Mejuto and I came up with the idea that El Hormigón deserved to be more than the occasional and changing scenario of one of his stories, and that my inseparable Browning would fit like a finger up... sorry, like a glove to the toxic atmosphere of the place. We discussed it and, by the third drink, came to the conclusion that he could do whatever he wanted as long as I didn't expect anything from him beyond some witty one-liners: it was too much effort. If the content is not to his liking, blame him for encouraging me and leaving me stranded.
The Geology of Iberia: A Geodynamic Approach
Taking a new global approach, this unique book provides an updated review of the geology of Iberia and its continental margins from a geodynamic perspective. Owing to its location close to successive plate margins, Iberia has played a pivotal role in the geodynamic evolution of the Gondwanan, Rheic, Pangea, Tethys s.l. and Eurasian plates over the last 600 Ma of Earth's history. The geological record starts with the amalgamation of Gondwana in the Neoproterozoic succeeded by the rifting and spreading of the Rheic ocean; its demise, which led to the amalgamation of Pangea in the late Paleozoic; the rifting and spreading of several arms of the Neotethys ocean in the Mesozoic Era and their ongo...
Advances in Artificial Intelligence
This book constitutes the refereed proceedings of the 18th Conference of the Spanish Association for Artificial Intelligence, CAEPIA 2018, held in Granada, Spain, in October 2018. The 36 full papers presented were carefully selected from 240 submissions. The Conference of the Spanish Association of Artificial Intelligence (CAEPIA) is a biennial forum open to researchers from all over the world to present and discuss their latest scientific and technological advances in Antificial Intelligence (AI). Authors are kindly requested to submit unpublished original papers describing relevant research on AI issues from all points of view: formal, methodological, technical or applied.
Routes to Reform
This is an open access title available under the terms of a CC BY-NC-ND 4.0 International licence. It is free to read on the Oxford Academic platform and offered as a free PDF download from OUP and selected open access locations. The key to sustained and equitable development in Latin America is high quality education for all. However, coalitions favoring quality reforms in education are usually weak because parents are dispersed, business is not interested, and much of the middle class has exited public education. In Routes to Reform, Ben Ross Schneider examines education policy throughout Latin America to show that reforms to improve learning--especially making teacher careers more meritoc...
Molecular Modeling and Prediction of Bioactivity
Much of chemistry, molecular biology, and drug design, are centered around the relationships between chemical structure and measured properties of compounds and polymers, such as viscosity, acidity, solubility, toxicity, enzyme binding, and membrane penetration. For any set of compounds, these relationships are by necessity complicated, particularly when the properties are of biological nature. To investigate and utilize such complicated relationships, henceforth abbreviated SAR for structure-activity relationships, and QSAR for quantitative SAR, we need a description of the variation in chemical structure of relevant compounds and biological targets, good measures of the biological properti...
Rapport sur le developpement dans le monde 2018
Chaque annee, le Rapport sur le developpement dans le monde de la Banque mondiale met en vedette un sujet d'importance capitale pour le developpement mondial. Le Rapport sur le developpement dans le monde 2018 - APPRENDRE pour realiser la promesse de l'education - est le premier consacre integralement a l'education. Et le moment s'y prete particulierement : l'education a toujours ete essentielle au bien-etre de l'etre humain, mais elle l'est plus encore en cette periode de rapides mutations economiques et sociales. Le meilleur moyen de preparer les enfants et les jeunes a l'avenir est de placer l'apprentissage au centre de toutes les interventions de promotion de l'education. Le Rapport sur ...
Cuba and Africa, 1959-1994
A history of Atlantic solidarity between Cuba and Africa, in struggle for African independence from colonial powers The Cuban people hold a special place in the hearts of the people of Africa. The Cuban internationalists have made a contribution to African independence, freedom, and justice, unparalleled for its principled and selfless character.’ As Nelson Mandela states, Cuba was a key participant in the struggle for the independence of African countries during the Cold War and the definitive ousting of colonialism from the continent. Beyond the military interventions that played a decisive role in shaping African political history, there were many-sided engagements between the island an...
Achieving World-Class Education in Brazil
An evaluation of Brazil's educational policies and the advances in basic education over the past 15 years as well as recommendations for future advances.
Computational studies of RNA and DNA
This book integrates modern computational studies of nucleic acids, ranging from advanced electronic structure quantum chemical calculations through explicit solvent molecular dynamics (MD) simulations up to mesoscopic modelling, with the main focus given to the MD field. It gives an equal emphasis to the leading methods and applications while successes as well as pitfalls of the computational techniques are discussed.
