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Molecular Mechanisms of Angiogenesis
  • Language: en
  • Pages: 501

Molecular Mechanisms of Angiogenesis

  • Type: Book
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  • Published: 2014-05-27
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  • Publisher: Springer

Angiogenesis is a multi-stage process that drives the generation of new blood and lymphatic vessels from pre-existing ones. It is highly active during embryogenesis, largely inactive during adulthood but reactivated during wound healing and under a number of pathological conditions including cancer and ocular diseases. In addition to endothelial cells, which line the walls of the vessels, several other cell types (pericytes, macrophages, progenitor cells...) also contribute to angiogenesis. A number of signaling pathways are activated and very finely tune the delicate morphogenetic events that ultimately lead to the formation of stable blood proof neovessels. This book reviews recent advances in our understanding of the molecular and cellular mechanisms of angiogenesis, with a focus on how to integrate these observations into the context of developmental, post-natal and pathological neovascularization. The book was published under the auspices of the French Angiogenesis Society. Most contributors are prominent members of this Society or international researchers who have actively contributed to the Annual Meetings of the Society.

ACTH Action in the Adrenal Cortex: From Molecular Biology to Pathophysiology
  • Language: en
  • Pages: 421

ACTH Action in the Adrenal Cortex: From Molecular Biology to Pathophysiology

By stimulating adrenal gland and corticosteroid synthesis, the adrenocorticotropic hormone (ACTH) plays a central role in response to stress. In this Research Topic, a particular attention has been given to the recent developments on adrenocortical zonation; the growth-promoting activities of ACTH; the various steps involved in acute and chronic regulation of steroid secretion by ACTH, including the effect of ACTH on circadian rhythms of glucocorticoid secretion. The Research Topic also reviews progress and challenges surrounding the properties of ACTH binding to the MC2 receptor (MC2R), including the importance of melanocortin-2 receptor accessory protein (MRAP) in MC2R expression and funct...

Chagas disease novel drug targets and treatments
  • Language: en
  • Pages: 129
Encyclopedic Reference of Vascular Biology & Pathology
  • Language: en
  • Pages: 384

Encyclopedic Reference of Vascular Biology & Pathology

  • Type: Book
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  • Published: 2013-12-19
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  • Publisher: Springer

This reference provides a synthesis of the whole field of vascular biology, from the latest advances in the study of the structure and function of blood vessels to recent investigations of their interaction with blood cells, with non-cellular constituants of the blood, or with cells of the neighbouring tissue. The latest results from tumor angiogenesis to the latest advances in atherosclerosis research are discussed by leading experts in the field. Together with the CD-ROM this guarantees both researchers and clinicians quick and easy access to all relevant information.

Peptide Growth Factors
  • Language: en
  • Pages: 624

Peptide Growth Factors

  • Type: Book
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  • Published: 1991
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  • Publisher: Unknown

None

Collected Papers from the National Cancer Center Research Institute
  • Language: en
  • Pages: 604

Collected Papers from the National Cancer Center Research Institute

  • Type: Book
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  • Published: 1991
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  • Publisher: Unknown

None

Cellular and Molecular Biology of the Adrenal Cortex
  • Language: en
  • Pages: 348

Cellular and Molecular Biology of the Adrenal Cortex

None

Molecular and Clinical Advances in Pituitary Disorders-1993
  • Language: en
  • Pages: 300
Trophoblasts
  • Language: en
  • Pages: 249

Trophoblasts

This volume explores the latest approaches used to assess trophoblast angiogenesis, transport function, cellular respirations, migration, and invasion. The chapters in this book cover topics such as various methods to study and manipulate primary trophoblast cells; strategies using liposomes to deliver biomolecules to trophoblasts; in vitro models of the placenta that emulate the cellular interactions in the 3D uterine environment; and models exploring heterogenous cell types and 3D-organoid structures that represent cell-to-cell interactions in vivo. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists ...

L'Angiogenèse
  • Language: fr
  • Pages: 152

L'Angiogenèse

En 1989, la découverte du facteur de croissance de l’endothélium vasculaire marquait une étape importante de la recherche anti-cancer. La lutte contre l’angiogenèse tumorale constitue un des grands succès des thérapies modernes du cancer, celles qui ciblent directement les mécanismes à l’œuvre dans la formation et la progression des cancers. Aujourd’hui les traitements anti-angiogènes sont devenus une réalité et la persévérance des recherches a pu aboutir à mettre à disposition des cliniciens plusieurs molécules actives. Il fallait découvrir quelles voies de signalisation aboutissaient à l’angiogenèse, quels stimuli mettaient en branle ces voies, quelles régula...