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Progress in Medicinal Chemistry provides a review of eclectic developments in medicinal chemistry. This volume continues in the serial's tradition of providing an insight into the skills required of the modern medicinal chemist; in particular, the use of an appropriate selection of the wide range of tools now available to solve key scientific problems. - Presents the latest research in the field of drug discovery - Publishes on a twice yearly basis to bring you the most innovative updates in medicinal chemistry - Available as an online resource via ScienceDirect
James Jeffreys has mysteriously disappeared following an accident. Dr Albert Anderson, the chief medical officer at BCG, awakens after a 5 year coma in 2017. Isolated and unable to communicate with the outside world, he learns of the developments that have transpired under the new military police state. The 2009 pandemic has reduced the world population by 1/3, and the ensuing chaos creates a financial, political, and religious climate unimaginable; but previously predicted. As Anderson is trying to figure out where he is and how he got there, the Jeffreys family makes a disturbing discovery in their home, launching a search which leads to a shocking turn of events. When BCG CEO Donald Parsons realizes there is a glitch in the project, things start going horribly wrong. Learning of Anderson and Jeffreys whereabouts or their fate, becomes the all consuming focus of the US military police, as well as a mysterious and dangerously powerful Italian man, Giovanni. Science, politics, and prophecy all converge on the success or failure of the ALTA project. Only a small group of individuals understand the true implications of the ALTA project, and how it could change the world forever.
Fragment-based drug discovery (FBDD) is a new paradigm in drug discovery that utilizes very small molecules - fragments of larger molecules. It is a faster, cheaper, smarter way to do drug discovery, as shown by the number of pharmaceutical companies that have embraced this approach and the biotechnology companies who use fragments as their sole source of drug discovery. Fragment-Based Drug Discovery: A Practical Approach is a guide to the techniques and practice of using fragments in drug screening. The emphasis is on practical guidance, with procedures, case studies, practical tips, and contributions from industry. Topics covered include: an introduction to fragment based drug discovery, w...
An integrated overview of modern approaches to lead discovery Lead generation is increasingly seen as a distinct and success-determining phase of the drug discovery process. Over recent years, there have been major advances in the understanding of what constitutes a good lead compound and how to improve the chances of finding such a compound. Written by leading scientists and established opinion leaders from industry and academia, this book provides an authoritative overview of the field, as well as the theory, practice, and scope, of the principal Lead Generation Approaches in Drug Discovery, including: The evolution of the lead discovery process, key concepts, current challenges, and futur...
Aus dem bestehenden Material der "Encyclopedia of Reagents for Organic Synthesis" (EROS) werden Paquette und die Herausgeber 500 bevorzugte Reagenzien auswählen, die dann in 4 Bände entsprechend ihrer Klassifikation eingeteilt werden, z.B. Oxidations- und Reduktionsreagenzien. Die endgültigen Titel der Bände werden festgelegt, sobald die Auswahl der 500 Reagenzien vorgenommen wurde. Jeder Band wird sich in Umfang und Struktur an EROS orientieren, d.h. er verfügt über eine Einleitung, die ausgewählten Reagenzien erscheinen in alphabetischer Reihenfolge, und es gibt jeweils einen Index zu Reagenzien, Autoren und Themenkomplexen. Für jedes Reagenz werden die physikalischen und chemischen Daten detailliert angegeben, so daß der Leser den Gebrauch der jeweiligen Reagenz versteht und sicher mit ihr arbeiten kann. (01/99)
The founder and CEO of Park West Gallery, Albert Scaglione, tells the story of how he created the largest art dealer in the world.
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Global Pentecostalism and Charismatic Christianity in all its diversity is the fastest expanding religious movement in the world today. Allan Anderson, a former Pentecostal minister and a leading authority on global Pentecostalism, aims to make more visible the 'non-western' nature of Pentecostalism without overlooking the importance of the movement emanating from North America. Offering an innovative interpretation of Pentecostalism, he takes seriously the contributions of the Majority World to its development and, concentrating on its history and theology, reflects on the movement's development and significance throughout the world. Anderson also examines those theological issues that helped form a distinctive spirituality and how this relates to different peoples and their cultures. Finally, Anderson discusses the development of Pentecostal and Charismatic Christianity in the different countries from its origins at the beginning of the twentieth century to its theological emphases in the present, together with the impact of the processes of globalization.