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Cullin-RING Ligases and Protein Neddylation
This book summarizes all the important aspects of CRLs (Cullin-RING E3 Ubiquitin Ligases), while providing details of mechanistic specifics that go beyond protein ubiquitination and neddylation. Ubiquitin ligases, including the CRLs, which are activated by neddylation, play an important role in diverse biological processes and are involved in various human diseases, particularly cancer. The book covers various topics, such as CRL structure, biology, genetics, its regulation by neddylation, its pivotal role in human disease, and its potential in drug discovery and targeted therapies. The book appeals to biochemists and biologists working in other fields, and, given the importance of CRLs in all aspects of cell biology and the great promise of targeting these complexes for therapy, is a valuable resource anyone interested in modern biology or medicine.
The key role of ubiquitination and sumoylation in signaling and cancer
Ubiquitination and Sumoylation are two important posttranslational modifications that play pivotal roles in a variety of biological functions. Although Ubiquitination is traditionally viewed as a critical mark targeting proteins for proteasome-dependent degradation, recent studies reveal that it also plays nonproteolytic functions. In contrast, Sumoylation is long thought not to target proteins for degradation, accumulating evidence suggests that it can serve a priming effect prerequisite for ubiquitination, thereby inducing protein ubiquitination and degradation. Thus, there is an important cross-talk between sumoylation and ubiquitination in determining protein fate. Deregulation in these two marks may cause aberrant activity of proteins and in turn contributes to cancer development. In this Research Topic, we accept review articles, perspectives, research articles covering any one or both of these two posttranslational modifications in regulating diverse signal transduction pathways and providing the novel insights in unraveling the puzzle as to how they may regulate cancer progression and metastasis.
Ubiquitin and Protein Degradation
Ubiquitin and Protein Degradation, Part B will cover chemical biology, ubiquitin derivatives and ubiquitin-like proteins, deubiquitinating enzymes, proteomics as well as techniques to monitor protein degradation. The chapters are highly methodological and focus on application of techniques. *Second part of the Ubiquitin and Protein Degration series *Topics include: E1 Enzymes, E2 Enzymes, E3 Enzymes, Proteasomes, and Isopeptidases.
A History of Contemporary Chinese Art
Chinese art has experienced its most profound metamorphosis since the early 1950s, transforming from humble realism to socialist realism, from revolutionary art to critical realism, then avant-garde movement, and globalized Chinese art. With a hybrid mix of Chinese philosophy, imported but revised Marxist ideology, and western humanities, Chinese artists have created an alternative approach – after a great ideological and aesthetic transition in the 1980s – toward its own contemporaneity though interacting and intertwining with the art of rest of the world. This book will investigate, from the perspective of an activist, critic, and historian who grew up prior to and participated in the great transition, and then researched and taught the subject, the evolution of Chinese art in modern and contemporary times. The volume will be a comprehensive and insightful history of the one of the most sophisticated and unparalleled artistic and cultural phenomena in the modern world.
The Substance of Fiction
Do the portrayals of objects in literary texts represent historical evidence about the material culture of the past? Or are things in books more than things in the world? Sophie Volpp considers fictional objects of the late Ming and Qing that defy being read as illustrative of historical things. Instead, she argues, fictional objects are often signs of fictionality themselves, calling attention to the nature of the relationship between literature and materiality. Volpp examines a series of objects—a robe, a box and a shell, a telescope, a plate-glass mirror, and a painting—drawn from the canonical works frequently mined for information about late imperial material culture, including the ...
Daily Report
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Daily Report
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The Age of Silver
The Age of Silver considers how commerce fueled the emergence of the novel around the globe, examining the evolution of epochal works of national literature from Don Quixote in 1605 to Robinson Crusoe in 1719.
Directory of Graduate Research
Faculties, publications and doctoral theses in departments or divisions of chemistry, chemical engineering, biochemistry and pharmaceutical and/or medicinal chemistry at universities in the United States and Canada.
