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Ubiquitin and Protein Degradation, Part B will cover chemical biology, ubiquitin derivatives and ubiquitin-like proteins, deubiquitinating enzymes, proteomics as well as techniques to monitor protein degradation. The chapters are highly methodological and focus on application of techniques. *Second part of the Ubiquitin and Protein Degration series *Topics include: E1 Enzymes, E2 Enzymes, E3 Enzymes, Proteasomes, and Isopeptidases.
Ubiquitin-proteasome-dependent proteolysis is central to an incredible multitude of processes in all eukaryotes, including the cell cycle, cell growth and differentiation, embryogenesis, apoptosis, signal transduction, DNA repair, regulation of transcription and DNA replication, transmembrane transport, endocytosis, stress responses, antigen presentation and other aspects of the immune response, the functions of the nervous system including circadian rhythms, axon guidance and acquisition of memory.This book tells the story of the ubiquitin system as we currently know it: from the regulation of basic cellular processes to quality control and the pathogenetic mechanisms of disease, from X-ray crystallography of the 26S proteasome to the interaction between substrates and their ligases, to the development of mechanism-based drugs, and to target-specific aberrant processes.
BLOOM is a collection of love stories presented as a mixtape: each of the stories is paired with a song, its soundtrack. The stories explore romantic comedy, eroticism, joy, grief, friendship, and romance through a lens mostly centred on female protagonists. In BLOOM Becky Varley-Winter showcases these stories as colourful blooms, filmic stories inspired by the likes of Andrea Arnold, Tove Jansson, and Elena Ferrante.
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DigiCat Publishing presents to you this special edition of "Carried by Storm" (A Novel) by May Agnes Fleming. DigiCat Publishing considers every written word to be a legacy of humankind. Every DigiCat book has been carefully reproduced for republishing in a new modern format. The books are available in print, as well as ebooks. DigiCat hopes you will treat this work with the acknowledgment and passion it deserves as a classic of world literature.
Women have had a complex experience in African American culture. The first work of its kind, this encyclopedia approaches African American literature from a Women's Studies perspective. While Yolanda Williams Page's Encyclopedia of African American Women Writers provides biographical entries on more than 150 literary figures, this book is much broader in scope. Included are several hundred alphabetically arranged entries on African American women writers, as well as on male writers who have treated women in their works. Entries on genres, periods, themes, characters, historical events, texts, places, and other topics are included as well. Each entry is written by an expert contributor and re...
'One of the funniest books of the year' - Guardian A collection of hilarious personal essays, poems and even amusement park maps on the subjects of insecurity, fame, anxiety, and much more from the charming and wickedly funny creator of Crazy Ex-Girlfriend. "It's nice to know someone as talented as Rachel is also pretty weird. If you're like me and love Rachel Bloom, this hilarious, personal book will make you love her even more." - Mindy Kaling "Rachel is one of the funniest, bravest people of our generation and this book blew me away." - Amy Schumer Rachel Bloom has felt abnormal and out of place her whole life. In this exploration of what she thinks makes her 'different', she's come to re...