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Published Scientific Papers of the National Institutes of Health
Each issue lists papers published during the preceding year.
Current Catalog
First multi-year cumulation covers six years: 1965-70.
Biological Reactive Intermediates
The concept that detoxication is the inevitable result of biotransformation of xenobiotic compounds by mammalian systems has undergone modification since it was first described. Indeed, despite the fact that R. T. Williams popularized the notion, he was among the first to caution that it was not possible to predict the biological activities of the resulting metabolites. It has become increasingly apparent in recent years that not only do many metabolites of drugs and other chemicals display biological activity but also in many instances these metabolites play an important role in initiating several forms of cancer and are the cause of a variety of types of toxicity. Thus it seems appropriate...
Contaminants in the Environment
This book provides a broad, interdisciplinary assessment of the hazards presented by direct and indirect environmental contaminants to humans. It explores disparate aspects of risk assessment ranging from molecular mechanisms to the practical and administrative issues of environmental management. The book's first three sections focus on principles relevant to living organisms in general, the fourth addresses the question of risks to human health, while the final section considers issues relevant to both "human" and "natural" environments.
EPA-600/7
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