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This volume of Current Topics in Membranes focuses on metal transmembrane transporters and pumps, a recently discovered family of membrane proteins with many important roles in the physiology of living organisms. The book summarizes the most recent advances in the field of metal ion transport and provides a broad overview of the major classes of transporters involved in homeostasis of heavy metals. Various families of the transporters and metal specificities are discussed with the focus on the structural and mechanistic aspects of their function and regulation. The reader will access information obtained through a variety of approaches ranging from X-ray crystallography to cell biology and bioinformatics, which have been applied to transporters identified in diverse biological systems, such as pathogenic bacteria, plants, humans and others. Field is cutting-edge and a lot of the information is new to research community Wide breadth of topic coverage Contributors of high renown and expertise
General history of California.
First in a series of reports by Browne (later continued by Rossiter Raymond). This is followed by a reprint of Edmund Randolph's 'Address on the history of California, from the discovery of the country to the year 1849' (p. 268-504, first published in 1860) and John W. Dwinelle's 'Address on the acquisition of California by the United States' (p. 306-321, first published in 1866. Also reprinted in this volume are James W. Taylor's report upon gold and silver mining East of the Rocky Mountains (p. 323-350) and the Dept. of the Interior's 'Circular in relation to mining claims' (p. 351-357), both of which were omitted in the earlier 320 p. issue.
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