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Wiring Principles of Cerebral Cortex
Cerebral cortex is probably the most complex biological network. Here many millions of individual neurons, the functional units of cortex, are interconnected through a massive yet highly organized pattern of axonal and dendritic wiring. This wiring enables both near and distant cells to coordinate their responses and generate a rich variety of cognitions and behaviours. When the wiring is damaged through disease or trauma it may reorganize but this may lead to characteristic pathological behaviours. While there have been significant advances in mapping cortical connectivity, the organizing principles and function of this connectivity are not well understood. On the one hand, there appears to...
Quantitative analysis of neuroanatomy
The true revolution in the age of digital neuroanatomy is the ability to extensively quantify anatomical structures and thus investigate structure-function relationships in great detail. Large-scale projects were recently launched with the aim of providing infrastructure for brain simulations. These projects will increase the need for a precise understanding of brain structure, e.g., through statistical analysis and models. From articles in this Research Topic, we identify three main themes that clearly illustrate how new quantitative approaches are helping advance our understanding of neural structure and function. First, new approaches to reconstruct neurons and circuits from empirical dat...
The History of Neuroscience In Autobiography
This fifth book of autobiographical essays by distinguished senior neuroscientists includes contributions by Samuel H. Barondes, Joseph E. Bogen, Alan Cowey, David R. Curtis, Ennio De Renzi, John S. Edwards, Mitchell Glickstein, Carlton C. Hunt, Lynn T. Landmesser, Rodolfo Llinas, Alan Peters, Martin Raff, Wilfred Rall, Mark R. Rosenzweig, Arnold Bernard Scheibel, and Gerald Westheimer. This collection of fascinating essays should inform and inspire students and working scientists alike. The general reader interested in science may also find the essays absorbing, as they are essentially human stories about commitment and the pursuit of knowledge.
Time for a People's Ombudsman Service - HC 655
In this report the Public Administration Select Committee (PASC) calls for a 'People's Ombudsman' and says the Parliamentary and Health Service Ombudsman (PHSO), which investigates complaints against the NHS and other government departments and agencies, is outdated. Citizens should have direct and more user-friendly access to the Ombudsman. None of the Ombudsmen created since the PHSO's operations were established in legislation 47 years ago have adopted the same restricted model as the Parliamentary Ombudsman. As a priority, the restriction on citizens' direct and open access to PHSO, known as the MP filter, must be abolished (as is already the case in respect of NHS complaints). PHSO must...
Neural Circuits Revealed
Deciphering anatomical and functional maps in the nervous system is a main challenge for both clinical and basic neuroscience. Modern approaches to mark and manipulate neurons are bringing us closer than ever to better understand nervous system wiring diagrams. Here we present both original research and review material on current work in this area. Together, this eBook aims to provide a comprehensive snapshot of some of the tools and technologies currently available to investigate brain wiring and function, as well as discuss ongoing challenges the field will be confronted with in the future.
Inferior Colliculus Microcircuits
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Billy Budd and Other Tales
A master of the american short story Included in this rich collection are: The Piazza, Bartleby the Scrivener, Benito Cereno, The Lightning-Rod Man, The Encantadas, The Bell-Tower, and The Town-Ho's Story.
