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Redesigning the Clinical Effectiveness Research Paradigm
Recent scientific and technological advances have accelerated our understanding of the causes of disease development and progression, and resulted in innovative treatments and therapies. Ongoing work to elucidate the effects of individual genetic variation on patient outcomes suggests the rapid pace of discovery in the biomedical sciences will only accelerate. However, these advances belie an important and increasing shortfall between the expansion in therapy and treatment options and knowledge about how these interventions might be applied appropriately to individual patients. The impressive gains made in Americans' health over the past decades provide only a preview of what might be possib...
Goethe and Zelter
Goethe and Zelter spent a staggering thirty-three years corresponding. Zelter's position as director of the Sing-Akademie zu Berlin and Goethe's location in Weimar resulted in a wide-ranging correspondence. Goethe's letters offer a chronicle of his musical development, from the time of his journey to Italy to the final months of his life, while Zelter's letters retrace his path from stonemason to Professor of Music in Berlin. The 891 letters that passed between these artists provide an important musical record of the music performed in public concerts in Berlin and in the private and semi-public soirées of the Weimar court. The legacy contains a wide spectrum of letters, casual and thoughtfully composed, spontaneous and written for publication, rich with the details of Goethe's and Zelter's musical lives.
Briefwechsel
Die Korrespondenz von Johann Heinrich Merck, ediert und kommentiert, ist eine editorische und bibliophile Kostbarkeit aus dem Jahrhundert des Briefes.Bekannt ist Johann Heinrich Merck vor allem als Freund und Briefpartner Goethes und der Herzogin Anna Amalia. Aber sein Werk und sein umfangreicher Briefwechsel haben einen deutlich weiteren Horizont. Als Schriftsteller, Rezensent und Verleger griff Merck in das literarische Geschehen seiner Zeit ein. Als Kunstkenner und -vermittler förderte und beriet er Künstler und Sammler. Den Fürsten unter seinen Briefpartnern galt er als Fachmann in agrarökonomischen Fragen. Nach 1780 führte ihn seine Leidenschaft für die Naturforschung auf das kaum...
Germans to America
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Mendelssohn
An extraordinary prodigy of Mozartean abilities, Felix Mendelssohn Bartholdy was a distinguished composer and conductor, a legendary pianist and organist, and an accomplished painter and classicist. Lionized in his lifetime, he is best remembered today for several staples of the concert hall and for such popular music as "The Wedding March" and "Hark, the Herald Angels Sing." Now, in the first major Mendelssohn biography to appear in decades, R. Larry Todd offers a remarkably fresh account of this musical giant, based upon painstaking research in autograph manuscripts, correspondence, diaries, and paintings. Rejecting the view of the composer as a craftsman of felicitous but sentimental, sac...
