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mTOR in Human Diseases
The mechanistic target of rapamycin (mTOR) is a major signaling intermediary that coordinates favorable environmental conditions with cell growth. Indeed, as part of two functionally distinct protein complexes, named mTORC1 and mTORC2, mTOR regulates a variety of cellular processes, including protein, lipid, and nucleotide synthesis, as well as autophagy. Over the last two decades, major molecular advances have been made in mTOR signaling and have revealed the complexity of the events implicated in mTOR function and regulation. In parallel, the role of mTOR in diverse pathological conditions has also been identified, including in cancer, hamartoma, neurological, and metabolic diseases. Through a series of articles, this book focuses on the role played by mTOR in cellular processes, metabolism in particular, and highlights a panel of human diseases for which mTOR inhibition provides or might provide benefits. It also addresses future studies needed to further characterize the role of mTOR in selected disorders, which will help design novel therapeutic approaches. It is therefore intended for everyone who has an interest in mTOR biology and its application in human pathologies.
The Glory of Yue
The Glory of Yue is the first translation into any Western language of the Yuejue shu, a collection of essays on history, literature, religion, architecture, economic thought, military science, and philosophy related to the ancient kingdoms of Wu and Yue, in present day eastern China.
Wuji Demon Saint
The boundless sky is blue and boundless. Swarms of thunderbirds and beasts soar unscrupulously between heaven and earth, supercilious. The whole body naturally sends out the breath of someone who outranks you, so that the birds and animals in the forest below trembled slightly and dared not move. Fortunately, the Thunderbird herd was not interested in them, just glanced at them lightly, then soared, turned into countless black spots and disappeared into the sky.
Antiquarianism and Intellectual Life in Europe and China, 1500-1800
This book is a project in comparative history, but along two distinct axes, one historical and the other historiographical. Its purpose is to constructively juxtapose the early modern European and Chinese approaches to historical study that have been called "antiquarian." As an exercise in historical recovery, the essays in this volume amass new information about the range of antiquarian-type scholarship on the past, on nature, and on peoples undertaken at either end of the Eurasian landmass between 1500 and 1800. As a historiographical project, the book challenges the received---and often very much under conceptualized---use of the term "antiquarian" in both European and Chinese contexts. R...
Singing on the River
In Singing on the River, Igor Chabrowski explores life conditions and work-song traditions of Sichuan boatmen demonstrating how they constructed their mentality and social identity in the turbulent first half of the twentieth century.
The New Cambridge Handbook of Contemporary China
Completely revised and updated, the New Cambridge Handbook of Contemporary China is an indispensable and manageable guide to the world's most populous nation. Emphasising the period from the 1990s, the book covers and includes the following subjects: a chronology detailing events since 1949; politics and law; biographies of eminent individuals; an annotated bibliography of books, journals and websites relevant to China in the 1990s and beyond; foreign relations, especially with the United States and Russia; the economy, including China's main economic reform programs and objectives; education; population and a gazetteer. With an excellent selection of figures, diagrams and maps, this book will be the standard reference to contemporary China for students, teachers, journalists, travelers, academic and government researchers, business people, policy-makers and general readers.
Walk on two sides and be the only one
In addition to the endless forest, there are countless lonely hills that stand strangely in every corner of the forest. In addition, there are countless Warcraft and beasts lurking in the forest, which makes those who want to cut some materials and take them back to make a fire only sigh and hesitate
