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The underlying mechanisms of Candida and candidiasis and promising new directions in drug discovery and treatment. • Reviews all aspects of this common fungal pathogen and its impact on human health, from the basic biology of Candida albicans to the clinical management of candidiasis. • Reviews the latest basic and clinical research, focusing on findings in genome variability, host-pathogen interactions, antifungal resistance and drug discovery, and diagnostics to foster better understanding and treatment of candidiasis. • Examines recent discoveries that have shed light on morphogenesis and the cell cycle, including how new findings on host responses may have applications for the diagnosis of blood-borne candidiasis.
This volume is based on the Proceedings of the International Conference on "Microbial Infections: Role of Biological Response Modifiers" held in Tampa, FL, May 29-31, 1991. The major purpose of this conference was to bring together in one forum prominent investigators from around the world studying a variety of microbial pathogens, including bacteria, viruses, and fungi, and the effects of biological response modifiers (BRM) on the immune response to these microorganisms. BRM have been widely utilized in the area of antitumor resistance and include not only experimental tumor cell vaccines, but also biologically active substances such as cytokines, i. e. , interferons, tumor necrosis factor,...
Colonization Control of Human Bacterial Enteropathogens in Poultry consists of papers presented at the International Symposium on Colonization Control of Human Bacterial Enteropathogens in Poultry. Organized into four parts, the book begins by discussing the environmental factors and sources associated with colonization control of human bacterial enteropathogens in poultry. It then describes the progress in the development of competitive exclusion as a treatment to prevent colonization of poultry by human bacterial enteropathogen. Presentations concerning the mechanisms of colonizationof chickens by Salmonella and Campylobacter are shown in the third part. Lastly, the book discusses the immunization aspects of controlling Salmonella commensal colonization of chickens. This book will stimulate and focus worldwide research that will accelerate progress toward the knowledge and technologies with which microbiologically safer, more wholesome poultry products can be made available toconsumers.
Osteoporosis is one of the most important diseases facing the ageing population because of the high prevalence of fractures, the enormous costs in health care funds required to deal with the consequence of these fractures, and the substantial effect in terms of suffering and disability. One-third of women over age 65 will have vertebral fractures, and the li fe-time risk ofhip fracture in white women (15%) is as great as that ofbreast, endometrial, and ovarian cancer combined. The life-time risk of hip fracture in men (5%) is as great as the risk of prostate cancer. Hip fracture is fatal in up to 20% of cases. One-half of survivors are unable to walk unassisted and 25% are confined to long-term ca re in nursing hornes. The recent awareness that osteo porosis is a treatable and partly preventable disease of the elderly, and not just the inevitable consequence of ageing, comes at a time of rapid progress in measurement of bone mass and in a better understanding of the physiology and pathophysiology of bone cell function.
A comprehensive survey of recent advances is given in this Update. The wide spectrum of experimental and clinical investigations include the pathophysiologic, diagnostic and therapeutic aspects.
"Infection in the Compromised Host" has become a classic chapter in textbooks devoted to infectious diseases and internal medicine. The numbers of compromised hosts are increasing in the era of modem medicine because of our expanded capabilities to deal with difficult diseases, especially neoplasms. As a consequence, microbiologic complications related to the intensive care administered to these patients are increasing as well. Under these circum stances, not only does the underlying illness create conditions favorable for the development of unusual infections, but often the therapy contributes to the acquisition of potential pathogens that turn into agents responsible for severe and frequen...
Proceedings of the Round Table Conference on Developments in Antibiotic Treatment of Respiratory Infections in the Hospital and General Practice, held in the Kurhaus, Scheveningen, The Netherlands, June 15-16, 1980
It is now widely accepted that there are important links between inactivity and lifestyle-related chronic diseases, and that exercise can bring tangible therapeutic benefits to people with long-term chronic conditions. Exercise and Chronic Disease: An Evidence-Based Approach offers the most up-to-date survey currently available of the scientific and clinical evidence underlying the effects of exercise in relation to functional outcomes, disease-specific health-related outcomes and quality of life in patients with chronic disease conditions. Drawing on data from randomized controlled trials and observational evidence, and written by a team of leading international researchers and medical and ...
Leading medical authorities and clinicians comprehensively review and critically assess the newest nutritional approaches to preventing or delaying disease processes to create the single most comprehensive resource for health professionals seeking to improve individual health outcomes through nutrition. Along the way these distinguished scientists develop specific nutrient recommendations and illuminate not only the relationship between diet on the one hand and cancer, cardiovascular disease, and diabetes on the other, but also the dietary prevention of cataracts, osteoporosis, and immune dysfunction. In addition, they examine the exciting current research linking nutritional status with the prevention of birth defects, as well as with the optimization of the health and intellectual capacity of children. Their pathbreaking reviews clearly spell out the public health implications of preventive nutrition strategies for the US and Europe, as well as emerging nations and developing countries worldwide.