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This book highlights progress and trends in the rapidly evolving field of complement-related drug discovery and spotlights examples of clinical applications. As an integral part of innate immunity and critical mediator in homeostatic and inflammatory processes, the human complement system has been identified as contributor to a large number of disorders including ocular, cardiovascular, metabolic, autoimmune, and inflammatory diseases as well as in ischemia/reperfusion injury, cancer and sepsis. In addition, complement is often involved in adverse immune reactions to biomaterials, cell and organ transplants or drug delivery systems. Although the complement cascade with its close to 50 extrac...
Communities in Contact represents the outcome of the Fourth International Leiden in the Caribbean symposium entitled From Prehistory to Ethnography in the circum-Caribbean. The contributions included in this volume cover a wide range of topics from a variety of disciplines - archaeology, bioarchaeology, ethnohistory and ethnography - revolving around the themes of mobility and exchange, culture contact, and settlement and community. The application of innovative approaches and the multi-dimensional character of these essays have provided exiting new perspectives on the indigenous communities of the circum-Caribbean and Amazonian regions throughout prehistory until the present.