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Antioxidants in Disease Mechanisms and Therapy
Antioxidants in Disease Mechanisms and Therapy presents molecular actions of natural and synthetic antioxidants and emphasizes the potential role in disease mechanisms and therapeutic strategies. The modulationof gene expression by the induction of antioxidant enzymes is a novel role beyond the direct antioxidant action. The volume explores the current state of knowledge on oxidants and antioxidants in disease processes, including arteriosclerosis, adult respiratory distress syndrome, cystic fibrosis, Down's syndrome, inflammation, cataract, age-related macular degeneration, afflications of the nervous system, AIDS, liver diseases, diabetes, skin diseases, and cancer. - Contains cutting-edge information on focused topics written by expert scientists - Provides the first in-depth treatment of novel compounds, such as melatonin and polyamines - Attempts molecular pathophysiology which links basic science and the clinic - Presents critical assessment of controversial topics
Oxidants and Antioxidants in Cutaneous Biology
Are free radicals and reactive oxygen species relevant to dermatopathology? Do antioxidants protect against free-radical-mediated cutaneous diseases and aging? To these and further current questions in the rapidly progressing field of basic and applied skin research, this up-to-date volume provides a scientific basis. It presents state-of-the-art reviews on the progress in detection of free radicals and antioxidants and their responses to environmental oxidative stressors. Furthermore, several expert contributions focus on the exciting developments in oxidative DNA damage and UVB- and UVA-induced signal transduction in skin. Finally, information is given on new antioxidant protection strategies against skin carcinogenesis and skin aging which may be fundamental for the pharmaceutical or skin-care products of tomorrow. Due to its unique and up-to-date collection of state-of-the-art contributions by many of the world's leading scientists in the field, this book will be essential reading for dermatologists, cosmetologists, pharmacologists and environmental toxicologists.
The Environmental Threat to the Skin
This text offers an overview of research and comment on the detrimental effects of ultraviolet radiation, chemical agents and other substances in the environment and will be of wide interest to dermatologists, toxicologists, environmental scientists, pharmacologists, oncologists and microbiologists.
Biophysical and Physiological Effects of Solar Radiation on Human Skin
This title has brought together a wide range of world class contributors to provide the reader with information on the clinical effects of solar radiation, such as inflammation, pigmentation, immune-supression, cancer and ageing, with emphasis on the ethnic or genetic background.
Roles of Vasopressin and Oxytocin in Memory Processing
The Roles of Vasopressin and Oxytocin in Memory Processing reviews research progress in a subfield of Behavioral Pharmacology concerned with vasopressin's (VP's) and oxytocin (OT's) roles in memory processing (MP). As hormones, VP is well-known for its pressor and antidiuretic action, and OT for its contribution to parturition and nursing. As neurotransmitters, they participate in a wide variety of self- and species-preserving functions expressed at psychological, physiological and behavioral levels. Advances in Pharmacology is available online on ScienceDirect — full-text online of volumes 48 onwards. Elsevier book series on ScienceDirect gives multiple users throughout an institution sim...
Hormones and Signaling
Hormones and Signaling focuses on the mechanisms of gene regulation at the cellular level. It also describes the actions of hormones in modulating gene regulation and animal development. - Glococorticoid and mineralcorticoid signaling - Orphan nuclear receptors - Nuclear receptor coactivators - Cytokines and STAT signaling - Coordination of cAMP signaling events through PKA anchoring - G protein-coupled extracellular Ca2+ (Ca2+0)-sensing receptor (CaR) - Pancreatic islet development - Genetic analysis of androgen receptors in development and disease - Antioprogestin regulable gene switch for induction of gene expression in vivo - Steroid receptor knockout model
HIV: Molecular Biology and Pathogenesis: Viral Mechanisms
The cumulative death toll from AIDS has reached 16.3 million individuals, and more than 33 million persons are currently living with HIV-1. Although it is one of the most-widely studied viruses, many mysteries remain about this pathogen. In this comprehensive two-volume set, HIV-1: Molecular Biology and Pathogenesis, leading investigators in HIV research present a timely picture of the molecular mechanisms which guide HIV-1 expression and replication and provide the most current clinical strategies for combating this virus. Twenty-six teams of experts unravel structure-function interactions of HIV-1 with host cells and the resulting pathological consequences, review strategies fo treatment, ...
Skin Aging
The topic of skin aging is of growing importance to all working in the field of dermatology, aesthetic medicine and cosmetic medicine. Two internationally well-known and leading experts in the field present a comprehensive state-of-the-art review on all aspects of skin aging. With its clear, concise and reader-friendly format this book has all the potential to become the Bible of skin aging. Every specialist interested in dermatology, aesthetic medicine, cosmetic science, cutaneous biology and aging research will find indispensable information of great value for his or her daily work.
Sun Protection in Man
"Sun Protection in Man" looks at the beneficial and harmful effects of solar radiation. The physiological consequences of sun exposure have been systematically studied starting at the end of the nineteenth century and we now have accumulated knowledge about how Caucasian and Asian skins reacts to solar radiation. The chemical effects of solar ultraviolet radiation have been analyzed with particular emphasis during the second half of the twentieth century. Research on micro-organisms has allowed us to understand the mechanisms of UV-induced mutagenesis and photosensitization. Studies with laboratory rodents have opened the path to the understanding of UV-induced immune-depression, carcinogene...
