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How Does Germline Regenerate?
A concise primer that complicates a convenient truth in biology--the divide between germ and somatic cells--with far-reaching ethical and public policy ramifications. Scientists have long held that we two have kinds of cells--germ and soma. Make a change to germ cells--say using genome editing--and that change will appear in the cells of future generations. Somatic cells are "safe" after such tampering; modify your skin cells, and your future children's skin cells will never know. And, while germ cells can give rise to new generations (including all of the somatic cells in a body), somatic cells can never become germ cells. How did scientists discover this relationship and distinction betwee...
What Is Regeneration?
The idea of regeneration -- Observations and experiments -- Mechanisms of regeneration -- Living systems and different scales.
Why Study Biology by the Sea?
For almost a century and a half, biologists have gone to the seashore to study life. The oceans contain rich biodiversity, and organisms at the intersection of sea and shore provide a plentiful sampling for research into a variety of questions at the laboratory bench: How does life develop and how does it function? How are organisms that look different related, and what role does the environment play? From the Stazione Zoologica in Naples to the Marine Biological Laboratory in Woods Hole, the Amoy Station in China, or the Misaki Station in Japan, students and researchers at seaside research stations have long visited the ocean to investigate life at all stages of development and to convene discussions of biological discoveries. Exploring the history and current reasons for study by the sea, this book examines key people, institutions, research projects, organisms selected for study, and competing theories and interpretations of discoveries, and it considers different ways of understanding research, such as through research repertoires. A celebration of coastal marine research, Why Study Biology by the Sea? reveals why scientists have moved from the beach to the lab bench and back.
The Darwinian Tradition in Context
The main goal of this book is to put the Darwinian tradition in context by raising questions such as: How should it be defined? Did it interact with other research programs? Were there any research programs that developed largely independently of the Darwinian tradition? Accordingly, the contributing authors explicitly explore the nature of the relationship between the Darwinian tradition and other research programs running in parallel. In the wake of the Synthetic Theory of Evolution, which was established throughout the 1930s, 1940s, and 1950s, historians and philosophers of biology devoted considerable attention to the Darwinian tradition, i.e., linking Charles Darwin to mid-Twentieth-Cen...
Frankenstein
The original 1818 text of Mary Shelley's classic novel, with annotations and essays highlighting its scientific, ethical, and cautionary aspects. Mary Shelley's Frankenstein has endured in the popular imagination for two hundred years. Begun as a ghost story by an intellectually and socially precocious eighteen-year-old author during a cold and rainy summer on the shores of Lake Geneva, the dramatic tale of Victor Frankenstein and his stitched-together creature can be read as the ultimate parable of scientific hubris. Victor, “the modern Prometheus,” tried to do what he perhaps should have left to Nature: create life. Although the novel is most often discussed in literary-historical term...
The Globalization of Wheat
In The Globalization of Wheat, Marci R. Baranski explores Norman Borlaug’s complicated legacy as godfather of the Green Revolution. Winner of the Nobel Peace Prize in 1970 for his role in fighting global hunger, Borlaug, an American agricultural scientist and plant breeder who worked for the Rockefeller Foundation, left a legacy that divides opinions even today. His high-yielding dwarf wheat varieties, known as miracle seeds, effectively doubled and tripled crop yields across the globe, from Kenya to India and Argentina to Mexico due to their wide adaptation. But these modern seeds also required expensive chemical fertilizers and irrigation, both of which were only available to wealthier f...
Bioethics in Action
A collection of first-person case studies that detail serious ethical problems in medical practice and research.
The Dynamics of Science
Millions of scientific articles are published each year, making it difficult to stay abreast of advances within even the smallest subdisciplines. Traditional approaches to the study of science, such as the history and philosophy of science, involve closely reading a relatively small set of journal articles. And yet many questions benefit from casting a wider net: Is most scientific change gradual or revolutionary? What are the key sources of scientific novelty? Over the past several decades, a massive effort to digitize the academic literature and equip computers with algorithms that can distantly read and analyze a digital database has taken us one step closer to answering these questions. The Dynamics of Science brings together a diverse array of contributors to examine the largely unexplored computational frontiers of history and philosophy of science. Together, they reveal how tools and data from automated textual analysis, or machine “reading,” combined with methods and models from game theory and cultural evolutionary theory, can begin to answer fundamental questions about the nature and history of science.
Can Microbial Communities Regenerate?
"You take antibiotics to fight an infection. Unfortunately, the treatment also kills the community of bacteria in your gut microbiome; you now have digestion issues. You might start eating yogurt to reintroduce good bacteria. Or, if the bacterial community is more significantly disordered, you might need a "fecal microbiota transplant" - a doctor transfers stool from a healthy donor into your gut. The new bacteria community thrives, and you can again digest your food. If all the same types of bacteria are present in this new community, has your microbiome "regenerated"? What if the bacteria are completely different, but they perform the same function? How do the answers to these questions ch...
