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Pharmacokinetic-Pharmacodynamic Model of Drugs and Their Pharmacokinetic Differences between Normal and Disease States
In the main frame of the above research topic, 16 contributions have been published including but not limited to the comparative pharmacokinetics between normal and disease status, the changes in the expression and function of drug-metabolizing enzymes and drug transporters in disease status and their related regulatory mechanisms, ADME/toxicity of drugs as well as their regulation, drug-drug interactions mediated by nuclear receptors, transporters and metabolic enzymes based on the methods and techniques of pharmacokinetics, transcriptomics, and metabolomics. However , the pharmacokinetic study is not only crucial in the development of new drugs, but also the study of pharmacokinetic-pharma...
Two Decades of Re-Emerging Russia: Challenges and Prospects
Russia has been re-emerging as a major political and economic power during the last decade. The leadership of Russia claims that the objectives of transition from the former one-party socialist system to a plural multiparty democratic system and centralised planning to market economy are largely achieved. Russia is politically stable and has demonstrated how new political institutions, multiparty system are functioning under three presidents. In the initial years after the disintegration of the Soviet Union, the Russian economy passed through different phases such as crisis, boom and recovery. Russia has largely succeeded in managing its political and economic relations with “Near Abroadâ€...
Corruption
The dangers of involvement in corruption need to be embedded in corporate strategy. Companies' response to these dangers must also be reflected in their practices, particularly if operating outside its own borders. This book guides managers through the complexity of bribery issues with advice on how to implement anti-corruption strategies.
Oral Bioavailability
Understand and assess the design, delivery, and efficacy of orally administered drugs A practical guide to understanding oral bioavailability, one of the major hurdles in drug development and delivery, Oral Bioavailability: Basic Principles, Advanced Concepts, and Applications is designed to help chemists, biologists, life science researchers, pharmaceutical scientists, pharmacologists, clinicians, and graduate and students become familiar with the fundamentals and practices of the science of oral bioavailability. The difference in rate and extent between a drug taken orally and the actual amount of a drug reaching the circulatory system, oral bioavailability is an essential parameter for de...
Electron Microscopy in Science and Engineering
This issue of Direction focuses on the rapid proliferation of electron microscopy (EM) for scientific as well as technological research. The content written by leading experts is intended to provide the capabilities of EM facilities, set at Indian Institute of Technology (IIT) Kanpur to solve various problems and caters to the needs of both internal and external users. The book provides a detailed and comprehensive viewpoint of the basic features and advanced capabilities of EM facilities to the scientific community. A large number of electron microscopes have been installed and utilized by researchers across various engineering and science departments; hence, this volume provides both breadth as well as depth of various EM facilities available at the institute.
Applications, Challenges, and the Future of ChatGPT
The rapid progress of artificial intelligence (AI) technologies has resulted in a complicated landscape for researchers and practitioners. Understanding and navigating the complexities of AI applications, particularly in the context of ChatGPT and its interactions with other AI tools, can be challenging. Researchers and academics need guidance to keep up with these technologies' evolving trends and implications, which leads to gaps in knowledge and implementation strategies. Additionally, the ethical and societal impacts of integrating AI into various domains remain a significant concern, requiring a comprehensive approach to address. Applications, Challenges, and the Future of ChatGPT provi...
Oral Bioavailability and Drug Delivery
ORAL BIOAVAILABILITY AND DRUG DELIVERY Improve the performance and viability of newly-developed and approved drugs with this crucial guide Bioavailability is the parameter which measures the rate and extent to which a drug reaches a user’s circulatory system depending on the method of administration. For example, intravenous administration produces a bioavailability of 100%, since the drugs are injected directly into the circulatory system; in the case of oral administration, however, bioavailability can vary widely based on factors which, if not properly understood, can result in a failure in drug development, adverse effects, and other complications. The mechanics of oral bioavailability...
