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The Placenta and Human Developmental Programming
Developmental programming is a rapidly advancing discipline of great importance to basic scientists and health professionals alike. This text integrates, for the first time, contributions from world experts to explore the role of the placenta in developmental programming. The book considers the materno-fetal supply line, and how perturbations of placental development impact on its functional capacity. Chapters examine ways in which environmental, immunological and vascular insults regulate expression of conventional and imprinted genes, along with their impact on placental shape and size, transport, metabolism and endocrine function. Research in animal models is integrated with human clinical and epidemiological data, and questions for future research are identified. Transcripts of discussions between the authors allow readers to engage with controversial issues. Essential reading for researchers in placental biology and developmental programming, as well as specialists and trainees in the wider field of reproductive medicine.
The Placenta and Human Developmental Programming
Developmental programming is a rapidly advancing discipline of great importance to basic scientists and health professionals alike. This text integrates, for the first time, contributions from world experts to explore the role of the placenta in developmental programming. The book considers the materno-fetal supply line, and how perturbations of placental development impact on its functional capacity. Chapters examine ways in which environmental, immunological and vascular insults regulate expression of conventional and imprinted genes, along with their impact on placental shape and size, transport, metabolism and endocrine function. Research in animal models is integrated with human clinical and epidemiological data, and questions for future research are identified. Transcripts of discussions between the authors allow readers to engage with controversial issues. Essential reading for researchers in placental biology and developmental programming, as well as specialists and trainees in the wider field of reproductive medicine.
Development of Cardiovascular Systems
This volume is a unique overview of cardiovascular development from the cellular to the organ level across a broad range of species. The first section focuses on the molecular, cellular, and integrative mechanisms that determine cardiovascular development. The second section has eight chapters that summarize cardiovascular development in invertebrate and vertebrate systems. The third section discusses the effects of disease and environmental and morphogenetic influences on nonmammalian and mammalian cardiovascular development. It includes strategies for the management of congenital cardiovascular malformations in utero and postnatally.
Fetus and Neonate: Physiology and Clinical Applications: Volume 1, The Circulation
The Fetus and Neonate is a series of practical, focused texts which concentrate on that critical period of human development, from late fetal to neonatal life. Each volume in the series examines a particular body system, looking at the physiological mechanisms which underlie the transition from intrauterine to extrauterine life, and the pathophysiological processes which may occur in this period. Each volume will consider the application of new basic scientific knowledge to the clinical situation. This series will be a valuable source of information to practitioners and postgraduate trainees in obstetrics, neonatology, paediatrics and reproductive medicine, as well as to basic scientists in these fields.
The Bleeding Edge
Capitalism likes us to believe in the steady, inevitable march of progress, from the abacus to the iPad. But the historical record tells of innumerable roads not taken, all of which could have led to better, more equal worlds, and still can. Academic and activist Bob Hughes puts flesh on the bones of the idea that 'another world is possible', using as evidence the technology that capitalism claims as quintessentially its own: the computer in all its forms. Contrary to popular belief capitalism does not do innovation well – instead suppressing or appropriating it. This book shows that great innovations have never emerged from capitalism per se, but always from the utopian moments that occur...
Modern Graphics Communication
This full-color text offers a clear introduction and detailed reference for creating and interpreting technical drawings, whether using 2D CAD or 3D modeling. The important role that 3D CAD databases play in design and documentation is a central emphasis. Superbly integrated illustrations, step-by-step instructions, and navigation features help you master key skills and knowledge. Throughout, the authors demonstrate 3D and 2D drawing skills and CAD usage in the context of real-world practice in today's leading disciplines. They combine strong technical detail, real-world examples, and current standards, materials, industries, and processes—all in a format that is efficient, colorful, and v...
Cherish the Exception
On a warm September day in 1957, author John Allen Resko walked through the gates of Saint Charles into a world he was ill prepared to confront. He had no clear plan for the future and didn’t possess the financial means to follow another path. After concluding that the religious life and his temperament did not mesh, Resko, who had spent nine years pursuing a religious vocation, walked away. A continuation of The Gates of Saint Charles, Cherish the Exception narrates how his life evolved into something happy and unpredictable. Resko discusses how he reeducated himself, earned a doctorate from the University of Illinois, and began a successful scientific career in Oregon. With humor, Resko shares how he adapted to his new life in the scientific world, including his marriage and his research work in the area of hormones and behavior in nonhuman primates. Cherish the Exception offers a unique personal perspective of how Resko was able to reconcile his religious with scientific beliefs.
Epigenetics and Cancer
Genes interact with the environment, experience, and biology of the brain to shape an animal’s behavior. This latest volume in Advances in Genetics, organized according to the most widely used model organisms, describes the latest genetic discoveries in relation to neural circuit development and activity. Explores the latest topics in neural circuits and behavior research in zebrafish, drosophila, C.elegans, and mouse models Includes methods for testing with ethical, legal, and social implications Critically analyzes future prospects
