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pH Deregulation as the Eleventh Hallmark of Cancer
pH Deregulation as the Eleventh Hallmark of Cancer presents key concepts about pH deregulation in a concise and straight-forward manner. The book discusses topics such as pH regulation and metabolism, sodium hydrogen exchanger, monocarboxylate transporter, V-ATPase proton pump, carbonic anhydrases, and voltage gated sodium channels. In addition, it covers clinical and therapeutic implications and future perspectives. This is a valuable resource for researchers, oncologists, students and members of the biomedical and medical fields who want to learn more about the role of pH deregulation in cancer treatment. pH deregulation can improve the outcome of classical treatments without adding toxici...
Using New Metabolic Approaches to Target and Eradicate Cancer Stem Cells
Topic Editors MPL and FS hold a minority interest in Lunella Biotech, Inc.
Handbook on Immunosenescence
This authoritative handbook covers all aspects of immunosenescence, with contributions from experts in the research and clinical areas. It examines methods and models for studying immunosenescence; genetics; mechanisms including receptors and signal transduction; clinical relevance in disease states including infections, autoimmunity, cancer, metabolic syndrome, neurodegenerative diseases, frailty and osteoporosis; and much more.
Microbial Biochemistry
Microbial physiology, biochemistry and genetics allowed the formulation of concepts that turned out to be important in the study of higher organisms. In the first section, the principles of bacterial growth are given, as well as the description of the different layers that enclose the bacterial cytoplasm, and their role in obtaining nutrients from the outside media through different permeability mechanism described in detail. A chapter is devoted to allostery and is indispensable for the comprehension of many regulatory mechanisms described throughout the book. Another section analyses the mechanisms by which cells obtain the energy necessary for their growth, glycolysis, the pentose phospha...
The Genetics of African Populations in Health and Disease
A pioneering work that focuses on the unique diversity of African genetics, offering insights into human biology and genetic approaches.
Cancer
In this book the authors suggest that a 'dysmethylation syndrome' may affect the vital regulation of cell growth, metabolism and mitosis, and may then lead to cancer. These dysmethylations (which may be hyper- or hypo-methylations) affect not only the expression of the genes involved in growth and mitosis, but also the activity of enzymes such as phosphatase PP2A, which is assembled after methylation. This phosphatase limits the effects of the trophic kinases activated by growth factors or oncogenes. In the neurones, the syndrome associated with a deficit in the methylation of phosphatase and other substrates favours the accumulation of hyperphosphorylated proteins, as in Alzheimer's disease. This would mean that cancer and Alzheimer's disease, as well as Biermer's anaemia, are linked to cellular methylations.
