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August Harder is the primogenitor of the Harder family in Arkansas. He came as a child of five to the Sugarloaf valley in southern Sebastian County with his uncle and aunts. Forced by the depredations of marauders in the Civil War to move into Fort Smith, he married, had a family, and remained there the rest of his life. Around 1899 August began a family history and continued it until the last entry three months before his death in 1920. It is his history that forms the basis of this present work. The author places August and Louise and their family into the milieu of nineteenth century western Arkansas. He provides a synopsis of Augusts ancestors and shows how his family and descendants have flourished from pioneer days to present times.
August Harder is the primogenitor of the Harder family in Arkansas. He came as a child of five to the Sugarloaf valley in southern Sebastian County with his uncle and aunts. Forced by the depredations of marauders in the Civil War to move into Fort Smith, he married, had a family, and remained there the rest of his life. Around 1899 August began a family history and continued it until the last entry three months before his death in 1920. It is his history that forms the basis of this present work. The author places August and Louise and their family into the milieu of nineteenth century western Arkansas. He provides a synopsis of August's ancestors and shows how his family and descendants have flourished from pioneer days to present times.
A hands-on guide to the use of quantitative methods and software for making successful business decisions The appropriate use of quantitative methods lies at the core of successful decisions made by managers, researchers, and students in the field of business. Providing a framework for the development of sound judgment and the ability to utilize quantitative and qualitative approaches, Data Driven Business Decisions introduces readers to the important role that data plays in understanding business outcomes, addressing four general areas that managers need to know about: data handling and Microsoft Excel®, uncertainty, the relationship between inputs and outputs, and complex decisions with t...
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For a long time, the tight junction (TJ) was known to form and regulate the paracellular barrier between epithelia and endothelial cell sheets. Starting shortly after the discovery of the proteins forming the TJ—mainly the two families of claudins and TAMPs—several other functions have been discovered, a striking one being the surprising finding that some claudins form paracellular channels for small ions and/or water. This Special Issue includes 43 articles covering numerous dedicated topics including pathogens affecting the TJ barrier, TJ regulation via immune cells, the TJ as a therapeutic target, TJ and cell polarity, function and regulation by proteins of the tricellular TJ, TJ as a regulator of cellular processes, organ- and tissue-specific functions, TJ as sensors and reacting to environmental conditions, and last but not least, TJ proteins and cancer.
Today’s CEO must be a global leader who also understands that parts of the business must be managed locally. Someone who sets a strategic vision, though industry and technology disruptions will surely threaten that vision. Someone who must live in the future to go to the future, while continuously creating economic and social value. Not an easy task. Harder Than I Thought is a fictional narrative that puts this increasingly complex job in context—by enabling you to walk alongside Jim Barton, the new CEO of Santa Monica Aerospace, as he steps into the role. Barton’s story, developed in consultation with seasoned, reallife CEOs, contains crucial lessons for all leaders hoping to master the new skills required to move into the Csuite.