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DNA Vaccination/Genetic Vaccination
Genetic / DNA immunization represents a novel approach to vaccine and immune therapeutic development. The direct injec tion of nucleic acid expression cassettes into a living host results in a limited number of its cells becoming factories for production of the introduced gene products. This host-inappropriate gene expression has important immunological consequences, resulting in the specific immune activation of the host against the gene delivered antigen. The recent demonstration by a number of laboratories that the induced immune responses are functional in experimental models against both specific infectious diseases and cancers is likely to have dramatic consequences for the develop men...
Designer Vaccines
Designer Vaccines: Principles for Successful Prophylaxis seeks answers to these important questions and explores how immunological knowledge can be applied in the formulation and delivery of vaccines. Instead of focusing on the rating of existing vaccines, this forward-thinking text looks to how new vaccines can be developed and existing ones improved upon. The book provides sound immunological theory and fact as a basis for solving vaccine design problems. Beginning with a discussion of disease and immunity to infection, Designer Vaccines: Principles for Successful Prophylaxis describes how events leading to immunity following infection must be considered in the rational design of vaccines. It also introduces the mucosal immune system and considers the special requirements of oral vaccines. Both viral and bacterial vectors for vaccine delivery are reviewed in detail.
Anti-Idiotypes, Receptors, and Molecular Mimicry
Here is an up-to-date review of important new methods and results in anti-idiotypes, receptors, and molecular mimicry. It begins with a discussion of the theoretical background of the anti-idiotypic network, it's role in the regulation of immune response, and the physical characteristics of anti-idiotypic antibodies. It then goes on to explore many exciting applications in such areas as insulin action, thyroid cell function, the neurosciences, cardiology, virology, pharmacology, and reproduction.
Innovation in Vaccinology
Prevention of infectious diseases by vaccination is one of the most significant achievements of modern medicine. During the 20th century, the average human life span in the developed world was about 70 years and it is expected to increase, with a significant portion of this increase directly attributed to vaccination. Since the first empiric vaccination trials, knowledge and technology have enormously evolved and new vaccination strategies are emerging on the market. Indeed, in spite of the great success, conventional vaccination strategies sometimes may result ineffective and, above all, may raise safety concerns. The aim of this book is to provide an overview of some of the technology plat...
Organophosphorus Chemistry
Organophosphorus Chemistry provides a comprehensive and critical review of the recent literature. Coverage includes phosphines and their chalcogenides, phosphonium salts, low coordination number phosphorus compounds, penta- and hexa- coordinated compounds, quiquevalent phosphorus acids, nucleotides and nucleic aicds, ylides and related compounds, phosphazenes and the application of physical methods in the study of organophosphorus compounds. This is the 40th in a series of volumes which first appeared in 1970 under the editorship of Stuart Trippett and which covered the literature of organophosphorus chemistry published in the period from January 1968 to June 1969, citing some 1370 publications. The present volume covers the literature from January 2009 to January 2010, citing more than 2200 publications, continuing our efforts to provide an up to date survey of progress in an area of chemistry that has expanded significantly over the past 40 years.
Modern Vaccinology
The recent developments in modern vaccinology are mainly based on: (i) cloning of microbial genes into recombinant vectors containing genetic information for expression of desired neutralizing immunogens; (ii) alternatives of attenuated vectors with deleted genes permitting the insertion of several foreign genes expressing antigens exposed to the host immune system during the abortive replication of such vectors; (iii) combined vaccines with the aim to protect against many diseases with a limited number of administrations; (iv) evidence demonstrating the ability of animals to respond serologically to DNA injections considered as a potential method of vaccination; (v) the possibility to manip...
Advances in Virus Research
Advances in Virus Research
Immunomodulation in Domestic Food Animals
Immunomodulation in Domestic Food Animals covers the developments in the immunology and regulation of the immune response in domestic food animals. This book is organized into four parts encompassing 12 chapters that describe numerous factors affecting an immune response of animals and the management of these factors for food animal production. Part I provides an overview of the basic concepts of immunomodulation and the rationale for manipulating the immune response in food animals. Part II contains information on immunopotentiation using chemicals and a thorough discussion of adjuvant use. The molecular biology and in vivo use of cytokines in food animals is presented in Part III. Lastly, Part IV discusses physiologically regulated immunomodulation, including nutritional modulation of the immune response and neuroendocrine-immune interactions. This book is of great value to immunologists, microbiologists, and feed scientists and researchers.
