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In vivo Cell Biology of Cerebral Cortical Development and Its Related Neurological Disorders: Cellular Insights into Neurogenesis and Neuronal Migration
The brain consists of a complex but precisely organized neural network, which provides the structural basis of higher order functions. Such a complex structure originates from a simple pseudostratified neuroepithelium. During the developing mammalian cerebral cortex, a cohort of neural progenitors, located near the ventricle, differentiates into neurons and exhibits multi-step modes of migration toward the pial surface. Tight regulation of neurogenesis and neuronal migration is essential for the determination of the neuron number in adult brains and the proper positioning of excitatory and inhibitory neurons in a specific layer, respectively. In addition, defects in neurogenesis and neuronal...
Séminaire de Probabilités XXXVIII
Besides a series of six articles on Lévy processes, Volume 38 of the Séminaire de Probabilités contains contributions whose topics range from analysis of semi-groups to free probability, via martingale theory, Wiener space and Brownian motion, Gaussian processes and matrices, diffusions and their applications to PDEs. As do all previous volumes of this series, it provides an overview on the current state of the art in the research on stochastic processes.
Metabolic Modulation of Cellular Function
Metabolic pathways and their metabolites are gaining recognition as both sensitive biomarkers for pathological conditions and key modulators of cell fate. In the past, metabolic changes were considered a consequence of gene expression, metabolite control, or environmental changes such as starvation. However, extensive research in the last decade has demonstrated that metabolic changes respond to and influence cellular signaling. This crosstalk between metabolism and cellular signaling is mainly enabled by novel metabolite-mediated modulation of enzymatic activity of rate-limiting steps and post-translational and epigenetic modifications, for which metabolites serve as substrates.
MicroRNA in Regenerative Medicine
This work encapsulates the uses of miRNA across stem cells, developmental biology, tissue injury and tissue regeneration. In particular contributors provide focused coverage of methodologies, intervention and tissue engineering. Regulating virtually all biological processes, the genome's 1048 encoded microRNAs appear to hold considerable promise for the potential repair and regeneration of tissues and organs in future therapies. In this work, 50 experts address key topics of this fast-emerging field. Concisely summarizing and evaluating key findings emerging from fundamental research into translational application, they point to the current and future significance of clinical research in the miRNA area. Coverage encompasses all major aspects of fundamental stem cell and developmental biology, including the uses of miRNA across repair and regeneration, and special coverage of methodologies and interventions as they point towards organ and tissue engineering - Multi-colour text layout with 150 colour figures to illustrate important findings - Take home messages encapsulate key lessons throughout text - Short chapters offer focused discussion and clear 'voice'
The Developing Brain and its Connections
The Developing Brain and Its Connections describes the processes of neural development from neural induction through synaptic refinement. Each chapter explores specific mechanisms of development and describes key experiments from invertebrate and vertebrate animal models. By highlighting experimental methods and explaining how hypotheses evolve over time, readers learn essential facts while strengthening their appreciation of the scientific method. Discussions of neurodevelopmental disorders and therapeutic approaches to them bridge basic science discoveries with the clinical aspects of the field. Descriptions of recent work by student researchers and medical residents demonstrate career pat...
Neocortical Neurogenesis in Development and Evolution
Understanding the development and evolution of the mammalian neocortex The development of the mammalian brain, including the human brain, is inextricably linked with its evolution. Of particular interest is the development of the neocortex, the youngest part of the cerebral cortex in evolutionary terms, and the seat of such vital functions as sensory perception, generation of motor commands, and higher-order cognition. The process of neurogenesis is crucial to the formation and function of the neocortex, but this process is complex, based on species-specific adaptations of old and acquired new traits that subserve specific functions introduced during mammalian evolution. Neocortical Neurogen...
Stochastic Processes and Related Topics
This volume comprises selected papers presented at the 12th Winter School on Stochastic Processes and their Applications, which was held in Siegmundsburg, Germany, in March 2000. The contents include Backward Stochastic Differential Equations; Semilinear PDE and SPDE; Arbitrage Theory; Credit Derivatives and Models for Correlated Defaults; Three Intertwined Brownian Topics: Exponential Functionals, Winding Numbers and Local Times. A unique opportunity to read ideas from all the top experts on the subject, Stochastic Processes and Related Topics is intended for postgraduates and researchers working in this area of mathematics and provides a useful source of reference.
The Artemis Lunar Program
This book describes the future of the Artemis Lunar Program from the years 2017 to about 2030. Despite the uncertainty of the times and the present state of space exploration, it is likely that what is presented in this book will actually happen, to one degree or another. As history has taught us, predictions are often difficult, but one can see enough into the future to be somewhat accurate. As the Bible says, “Wesee thru the glass, but darkly.” All of the elements of the proposed program are described from several perspectives: NASA’s, the commercial space industry and our International partners. Also included are descriptions of the many vehicles, habitats, landers, payloads and experiments. The book tells the story of the buildup of a very small space station in a strange new lunar orbit and the descent of payloads and humans, including the first women and next man, to the lunar surface with the intent to evolve a sustained presence over time.
Tumors of the Central Nervous System, Volume 12
As in the case of its eleven predecessors in the series Tumors of the Central Nervous System, this volume is distinguished for its thorough approach, its roster of 92 distinguished contributors representing 11 different countries and its detailed examination of leading-edge technology and methods. Volume 12: Molecular Mechanisms, Children’s Cancer, Treatments, and Radiosurgery offers a comprehensive review of the diagnosis, therapy and prognosis of brain and spinal cord tumors. Coverage extends to a large number of tumor types, including neuroblastoma, medulloblastoma, meningioma and chordoma. Molecular profiling of brain tumors to select appropriate therapy in clinical trials of brain tum...
