This Special Issue of Bioengineering explores topics in Pediatric Neuro-Oncology ranging from preclinical modeling to translational research and neurocognitive outcomes. The topics are as below. Radiotherapy advances in pediatric brain tumors; Neurofibromatosis 1 and brain tumors in children; Molecular biology of pediatric gliomas and therapeutic insights; Embryonal tumors of the central nervous system in children-era of targeted therapeutics; Preclinical models in pediatric brain tumors-clinical relevance; Molecular neuroimaging of brain tumors; Palliative care for children with central nervous system malignancies; Neurocognitive and psychosocial outcomes following pediatric brain tumors.
The definitive book on reverse shoulder arthroplasty from leading orthopaedic shoulder surgeons This masterful book from top experts provides clinical insights on reverse shoulder arthroplasty gleaned from hands-on refinement of shoulder replacement techniques. Years of significant biomechanical and clinical research yielded invaluable knowledge that led to important improvements in functional outcome and implant durability. Among these refinements were stronger polyethylene derivatives, better ingrowth technology, and improved connection devices. As the durability and longevity of implant technology increased, younger active patients became suitable candidates for this procedure. In fact, R...
At the age of ten, Lily is forcefully torn from her mother's arms and sold at a Negro auction by her master, a man that Lily learns that day is her very own father. Seeking solace from such devastation, Lily secretly begins teaching herself to play her new master's piano: an instrument that she is forbidden from touching. Lily becomes an extraordinary pianist and gets away with secretly playing for fourteen years until the master's son, James, discovers her deceit. The "punishment" that James gives Lily starts her on an unprecedented journey that dramatically alters her life and influences the lives of thousands, including a man with great power. Lily's groundbreaking journey also unveils the secret altruistic love of a particular man who has been forbidden from expressing his love to her for years. But the question remains whether or not the strength of his love will be powerful enough to free Lily from the shackles of slavery and protect her dreams and her life while on her turbulent Journey to Winter Garden.
Established since 1986 as the definitive text and reference on use of radiation therapy for childhood cancer, Pediatric Radiation Oncology is now in its thoroughly revised and updated Fifth Edition. This edition reviews all significant recent clinical trials—including, for the first time, significant European clinical trials—and provides increased coverage of international and Third World issues. The latest cancer staging guidelines are included. New chapters cover psychosocial aspects of radiotherapy for the child and family and medical management of pain, nausea, nutritional problems, and blood count depression in the child with cancer. This edition also has full-color illustrations throughout. A companion website includes the full text and an image bank.
Winner of the Margaret Mead Award A classic, moving study of terminally ill children that emphasizes their agency and shows how we can relate to dying children more honestly “The death of a child,” writes Myra Bluebond-Langner, “poignantly underlines the impact of social and cultural factors on the way that we die and the way that we permit others to die.” In a moving drama constructed from her observations of leukemic children, aged three to nine, in a hospital ward, she shows how the children come to know they are dying, how and why they attempt to conceal this knowledge from their parents and the medical staff, and how these adults in turn try to conceal from the children their aw...
This world has changed. The future has changed. Childhood is changing. Raising children has never been more challenging - or potentially rewarding. It is becoming increasingly obvious that the world into which our young children will enter as adults, somewhere between 2020 and 2030, will be nothing like the world their parents grew up in, or even the world we currently inhabit. We need a better understanding of the world of the future in order to prepare our children and to 'future-proof' them. Future-proof Your Child is a very different kind of parenting book. It contains many useful, practical hints and tips but also focuses on the context for parenting and child development today. It convinces 21st-century parents of the need to change their approach to parenting future generations and is relevant, accessible, practical and inspirational. Future-proof Your Child highlights the critical importance of making choices, having conversations and consciously connecting with tomorrow's children today.
Essential Concepts in Molecular Pathology, Second Edition, offers an introduction to molecular genetics and the "molecular" aspects of human disease. The book illustrates how pathologists harness their understanding of these entities to develop new diagnostics and treatments for various human diseases. This new edition offers pathology, genetics residents, and molecular pathology fellows an advanced understanding of the molecular mechanisms of disease that goes beyond what they learned in medical and graduate school. By bridging molecular concepts of pathogenesis to the clinical expression of disease in cell, tissue and organ, this fully updated, introductory reference provides the backgroun...
Genetic Models and Molecular Pathways Underlying Autism Spectrum Disorders, Volume 241 provides the most recent information on the animal model systems that are available to study different forms of autism spectrum disorders. In addition to genetically engineered animals that uniquely model genetic forms of ASD, this volume also provides detailed chapters on a variety of specific topics, including An overview of genetic models of ASDs, Phenotypic modeling of ASD symptoms, Molecular mechanisms of NF1 model of ASD symptoms, Ube3a gene dosage disorders: molecular and circuit mechanisms of ASD, Circuit dysfunctions in ASD models, ERK signaling in genetic models of ASD, and more. - Presents a timely, comprehensive assessment of the field - Includes helpful summaries on current knowledge, gaps and future directions in autism research
How can we meet the special needs of children for emergency medical services (EMS) when today's EMS systems are often unprepared for the challenge? This comprehensive overview of EMS for children (EMS-C) provides an answer by presenting a vision for tomorrow's EMS-C system and practical recommendations for attaining it. Drawing on many studies and examples, the volume explores why emergency care for childrenâ€"from infants through adolescentsâ€"must differ from that for adults and describes what seriously ill or injured children generally experience in today's EMS systems. The book points the way to integrating EMS-C into current emergency programs and into broader aspects of health ca...