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Drug Discovery for Leishmaniasis
For human health, leishmaniasis is among the most important protozoan diseases, superseded only by malaria. Globally, 10 to 12 million people are infected with 1.5 million new cases every year. The development of cheaper new drugs is urgently needed for this neglected disease that is developing resistance to current treatments. Chemotherapy remains the only treatment option for the bulk of patients. However, this is largely unaffordable for most. In the past three years numerous advances in drug discovery have been made for treating this disease by exploiting diverging metabolic pathways between the Leishmania enzymes and their hosts, using nanotechnology to target the immune cell phagolysos...
A Primer on Corporate Governance
Mexico is a land inhabited by several indigenous civilizations and was conquered by Spain in 1521. The country is mostly a racial mix between the Spanish and native cultures. It is a traditionalist society where family, religion, and culture play a key role. The role of the marketplace is constrained by the government and local interest groups such as unions, political parties, commerce chambers, and private firms. The market for corporate control is scarce. Corporate governance codes are voluntary. Corporate ownership is concentrated with few institutional investors. Shareholder activism is uncommon. Corporate boards are single tier in nature. CEO duality is common practice. Boards are made...
Baseball Hacks
Baseball Hacks isn't your typical baseball book--it's a book about how to watch, research, and understand baseball. It's an instruction manual for the free baseball databases. It's a cookbook for baseball research. Every part of this book is designed to teach baseball fans how to do something. In short, it's a how-to book--one that will increase your enjoyment and knowledge of the game. So much of the way baseball is played today hinges upon interpreting statistical data. Players are acquired based on their performance in statistical categories that ownership deems most important. Managers make in-game decisions based not on instincts, but on probability - how a particular batter might fare ...
The World Factbook
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Assembly
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Computational Intelligence in Security for Information Systems
This book constitutes the refereed proceedings of the 4th International Conference on Computational Intelligence in Security for Information Systems, CISIS 2011, held in Torremolinos-Málaga, in June 2011 as a satellite event of IWANN 2011, the International Work-Conference on Artificial and Natural Neural Networks. The 38 revised full papers presented were carefully reviewed and selected from a total of 70 submissions. The papers are organized in topical sections on machine learning and intelligence, network security, cryptography, securing software, and applications of intelligent methods for security.
Joe Moakley's Journey
In November 1989 in El Salvador, six Jesuit priests and their two female housekeepers were rousted from their beds and shot as they lay face down on the ground. At first, the George H. W. Bush administration echoed the Salvadoran military's line that the rebels must have done it. When House Speaker Tom Foley tasked a senior congressman with investigating the murders, the people of El Salvador found an unlikely champion in the person of John Joseph Moakley, representative from South Boston. In Joe Moakley's Journey, Mark Robert Schneider charts one of the most unusual transformations in American politics. A native son of South Boston, Moakley was an effective and influential House member, whose greatest influence and legacy is, paradoxically, far from home in the fields of El Salvador and Central America. Though firmly, fiercely grounded in his hometown of South Boston--he never lived anywhere else--from the beginning of this investigation until his death in 2001, issues of Central American justice, peace, and economic development became Joe Moakley's cause.
