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Cardiac cell biology has come of age. Recognition of activated or modified signaling molecules by specific antibodies, new selective inhibitors, and fluorescent fusion tags are but a few of the tools used to dissect signaling pathways and cross-talk mechanisms that may eventually allow rational drug design. Understanding the regulation of cardiac hypertrophy in all its complexity remains a fundamental goal of cardiac research. Since the advancement of adenovirally mediated gene transfer, transfection efficiency is no longer a limiting factor in the study of cardiomyocytes. A limiting factor in considering cell transplantion as a strategy to repair the damaged heart is cell availability at the right time. Cardiac gap junctions, intercellular communication channels that allow electrical and metabolic coupling and play an important role in arrhythmogenesis are now understood to be exquisite sensors of cardiac change. The reports in this volume incLude elegant studies that made use of cutting edge technological advances and many specialized reagents to address these issues.
This book addresses biopsychosocial and transcultural determinants of suicide by self-immolation, populations at risk throughout the world and prevention strategies specifically designed for young women in fragile environments. Self-immolation, the act of burning oneself as a means of suicide, is rare in high-income countries, and is usually a symbolic display of political protest among men that generally receives international media coverage. In contrast, in low- and-middle-income countries it is highly prevalent, primarily affects women, and may be one of the most common suicide methods in regions of Central and South Asia and parts of Africa. Psychiatric conditions, like adjustment disord...
This book focuses on urban "green infrastructure" – the interconnected web of vegetated spaces like street trees, parks and peri-urban forests that provide essential ecosystem services in cities. The green infrastructure approach embodies the idea that these services, such as storm-water runoff control, pollutant filtration and amenities for outdoor recreation, are just as vital for a modern city as those provided by any other type of infrastructure. Ensuring that these ecosystem services are indeed delivered in an equitable and sustainable way requires knowledge of the physical attributes of trees and urban green spaces, tools for coping with the complex social and cultural dynamics, and an understanding of how these factors can be integrated in better governance practices. By conveying the findings and recommendations of COST Action FP1204 GreenInUrbs, this volume summarizes the collaborative efforts of researchers and practitioners from across Europe to address these challenges.
'The processes of internationalization, innovation and venture-creation in high-technology new ventures are inextricably intertwined. This is particularly true in the uncertain and troubled waters of the life sciences industry where startups with very uncertain futures are required to face significant challenges in short windows of opportunity. Navigating these waters is not straightforward, either for those immediately involved in it, or for those trying to understand it. This book is a must-read for anyone who is serious about understanding entrepreneurship in the biotechnology industry.' Alberto Onetti, CrESIT (Research Center for Innovation and Life Science Management), Italy In this tho...
Globalization has jarred the traditional role and competitiveness of small- and medium-sized enterprises. This masterful volume comprises leading scholars, policy makers and business leaders who have new insights and strategies for SMEs creating opportunities rather than being victims of globalization. The result is a breakthrough in our understanding of entrepreneurship in the global context. David B. Audretsch, Indiana University, Bloomington, US and WHU, Germany Small and medium-sized enterprises (SMEs) often have difficulty competing in the global economy unless they collaborate with domestic or foreign partners or with public sector organizations. This book addresses the resource levera...
A large number of family businesses operate in the luxury fashion sector which shows their importance as a source of growth, development and social and economic stability. This book analyses how a strategy of innovation in terms of products and processes can offer a competitive advantage to family businesses operating in the luxury fashion sector.