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Progress in Nucleic Acid Research and Molecular Biology
Progress in Nucleic Acid Research and Molecular Biology
Mechanism of Action of Antimicrobial and Antitumor Agents
This volume is the third in the series devoted to Antibiotics initiated by Springer Verlag in 1967. The first two volumes were devoted to the Mode of Action of Antibiotics and Biogenesis, respectively and were received graciously. During the intervening years these two works have been used often by research workers and students alike and have been quoted extensively. Although a number of other excellent treatises on antibiotics have appeared, the Springer series has set a standard for thoroughness and quality that meets the need of the scientific community. It is against this background that the present Editors set about the preparation of a third volume in the Series on Antibiotics. Since t...
Analogue-based Drug Discovery II
Born out of a project of the IUPAC's committee on Medicinal Chemistry and Drug Development, this reference addresses past and current strategies for successful drug analog development, extending the previously published volume by nine new analog classes and eight case studies. Like its precursor, this volume also contains a general section discussing universally applicable strategies for analog discovery and development. Spanning a wide range of therapeutic fields and chemical classes, the two volumes together constitute the first systematic approach to drug analog development. Of interest to virtually every researcher working in drug discovery and pharmaceutical chemistry.
Progress in Medicinal Chemistry
Progress in Medicinal Chemistry
Antiviral Drugs and Interferon: The Molecular Basis of Their Activity
Research on antiviral drugs and their mode of action in infected cells. in animals and in man. has led to a better understanding of the molecular pro cesses involved in virus replication. Screeninq of large numbers of natural and semisynthetic compounds resulted in the characterization of certain sub stances that had a limited efficiency as antiviral druqs. A few chemically synthesized compounds were also found to be effective as antiviral agents in the chemotherapy of human virus diseases. A major difficulty in the develop ment of effective antiviral agents has been the lack of selectivity. and toxicity for uninfected cells. of drugs that effectively inhibited virus replication in vitro. Fu...
Anthracycline Antibiotics in Cancer Therapy
F. M. MUGGIA When faced with the inadequacies of current cancer treatment, we prefer to look at what the future may hold. Quite often, we take for granted the past, preferring research into totally new areas. However, the persistent development of fertile soil may yield surprising rewards for those who choose to build on the knowledge of the past--hence, this symposium on anthracycline antibiotics. Although the anthracycline antibiotics represent much of the present and future of cancer treatment, their actual use c stretches back barely two decades to the pioneering efforts of Aurelio Di Marco, who characterized the antitumor properties of daunomycin and adriamycin. * The clinical applicati...
Applied Geology
This book includes a careful selection of significant contributions from international experts that were presented at the 6th AIGA Conference “Applied Geology: Approaches to Future Resource Management” that was held in the Courmayeur, Aosta Valley, Italy, from 27 - 29 June 2018. The following 7 areas are the main themes covered in this volume: · Applied Geology · Hydrogeology · Geological Exploration (underground) · Slope Instability, · Natural Hazards, Risk Assessment and Management, · Geo-resources and Sustainable Development · Application of Remote Sensing and Geographical Information Systems (GIS) The authors, from academia, research and industry present the latest state of the practice, new technologies, innovative methods and sustainable management in the field of Applied and Environmental Geology. This carefully edited work will be of value to academia, professionals, scientists and decision makers.
Antibiosis and Host Immunity
This book contains 32 chapters based on the corresponding papers delivered at the International Symposium on Antimicrobial Agents and Immunity, held in Siena, Italy on May 2-4, 1985 as a Satellite Symposium of the Third International Conference on Immunopharmacology, held in Florence, Italy on May 6-10, 1985. As editors we express our profound appreciation and gratitude to the authors who have contributed so richly to this volume, and we think that it may not be too much to hope that a new cadre of investigators and students will share this gratitude for these records of experience and insight into antibiotic and host-parasite interactions. We owe a very special gratitude to Mrs. Christine A...
