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Examining the European Commission's current range of practices for exercising control over the meaning and implementation of EU law, this book provides a comprehensive analysis of centralised EU enforcement. It describes the different practices available analysing their effectiveness and discussing the Commission's role in ensuring compliance.
Fragment-based drug discovery is a rapidly evolving area of research, which has recently seen new applications in areas such as epigenetics, GPCRs and the identification of novel allosteric binding pockets. The first fragment-derived drug was recently approved for the treatment of melanoma. It is hoped that this approval is just the beginning of the many drugs yet to be discovered using this fascinating technique. This book is written from a Chemist's perspective and comprehensively assesses the impact of fragment-based drug discovery on a wide variety of areas of medicinal chemistry. It will prove to be an invaluable resource for medicinal chemists working in academia and industry, as well as anyone interested in novel drug discovery techniques.
In partnership with the Jacques Monod Conference “Genetics, environment, signaling & synaptic plasticity in developmental brain disorders: from bench to bedside", the Frontiers in Neuroscience Journal announces an article collection that will highlight cutting-edge research presented at the 2022 meeting from Monday 11th Apr - Friday 15th Apr in Roscoff (Brittany). Neurodevelopmental Disorders (NDDs) are a highly heterogeneous group of disorders with a prevalence of 3% of the worldwide population. These disorders include Intellectual Disability (ID), autism spectrum disorder (ASD), attention deficit hyperactivity disorder, specific learning disorder, motor and language disorder, schizophren...
Written and designed to enhance your understanding of ocular function, structure, and anatomy, Adler's Physiology of the Eye is a classic, best-selling text that makes critical information easier to learn and retain. The fully revised 12th Edition continues the successful Adler's approach that connects basic science and clinical aspects in a user-friendly, highly visual format—ideal for study, review, and exam preparation. It captures the latest molecular, genetic, and biochemical discoveries and offers you unparalleled knowledge and insight into the physiology of the eye and its structures. - Covers the full structure and function of the eye and its related anatomy and makes the connectio...
In recent decades a growing number of studies have described cancer as a “we-disease”. Patients with cancer as well as intimate partners experienced psychological distress. Studies displayed that various relational factors (e.g., attachment style, mutuality, etc.) such as diverse close relationship processes (e.g., dyadic coping, communication, shared-decision making, etc.) have an impact on individual (e.g., physical and psychological health, quality of life) and dyadic (e.g., marital quality and satisfaction, sexual and reproductive health, etc.) outcomes. Thus, programs reducing psychological distress and enhancing dyadic processes were developed.
This book focuses on border deaths at sea. It unravels how the interplay of the law of the sea and rules on jurisdiction widen the opportunity for states to make and enforce rules outside their territory, and questions whether this is also accompanied with an obligation to respect the right to life under the European Convention on Human Rights (ECHR) when doing so. By embarking upon the challenge of analysing a cross-border phenomenon in which direct encounters between state agents and the victims are few through the lens of legal obligations, the book unearths avenues for arguing that the ECHR is applicable to border deaths on the high seas and showcases the Court’s creativity in bridging...
The goal of behavioral oncology is to understand and explain the role and impact of behaviors at all phases in the cancer trajectory -- from prevention and detection to diagnosis and early treatment, to survivorship, recurrence, and/or death. Each chapter includes summaries of recent research on cancer-related behavioral interventions, discussions of the studies summarized, and suggestions for future research. The book is a product of collaboration among members of the Behavioral Cooperative Oncology Group of the Mary Margaret Walther Program for Cancer Care Research at the Walther Cancer Institute in Indianapolis, Indiana.
The Oxford Handbook of Health Psychology brings together preeminent experts to provide a comprehensive view of key concepts, tools, and findings of this rapidly expanding core discipline.