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This book contains the proceedings of the symposium on Microbial Adhesion and Invasion. The meeting was the fifth in a series of symposia initiated and sponsored by the Department of Biochemistry, University of Alabama at Birmingham. We gratefully acknowledge the generous financial support of the following institutions and companies. -Department of Biochemistry, University of Alabama at Birmingham, Birmingham, Alabama, USA - National Institutes of Health, Bethesda, Maryland, USA -Alfa Laval International, AB, Tumba, Sweden -Procter and Gamble, Cincinnati, Ohio, USA -Amgen Inc., Thousand Oaks, California, USA -Johnson and Johnson, New Brunswick, New Jersey, USA We would like to express our appreciation to Agneta Hook, Timo Kostiainen, Mary Homonylo McGavin, Martin McGavin, Cindy Patti, Joe Patti and Anna-Marja Saamanen for their time and hard work making this symposium a success; and special thanks to Kay Cooper and Wade Butcher for help with the management of the symposium and editorial assistance with this book.
The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.
Presents a comprehensive review of current proteoglycan research, which is providing fresh insights into many major chronic diseases. The proteoglycans are a family of macromolecules which contain one or more glycosaminoglycan chains covalently bound to a core protein. Proteoglycans are a major component of the extracellular matrix of connective tissues and help to determine its volume, resiliency, and organization. They are an important medium through which nutrients, hormones, and other solutes are transported to cells, and they play a significant role in cell-cell interactions. Disturbances in proteoglycans occur in rheumatic and connective tissue disorders, degenerative bone disease, vascular disease, renal disease, and malignant disorders.
'A vivid, gripping story, beautifully handled, with a gem on every page' - Tracy Chevalier 'Once again J.C. Harvey has cleared the high bar in historical fiction by a mile.' - S. W. Perry 'Vibrant, twisting and compelling' - Minette Walters Summer 1630. The Swedish army is fighting its way down through Germany, with Jack Fiskardo and his company of scouts, or 'discoverers', fighting the guerrilla war ahead of the main advance. There are new allies to be made, new perils to overcome, new enemies to outwit and new adventures to pursue; but there is also a fortune for the taking, a mystery to be solved, and a destiny to fulfil - one that will see Jack brought face-to-face at last with his sworn enemy, Carlo Fantom. And in the wintry forests of Bohemia, that destiny will present Jack with an almost impossible choice - does he pursue his final vengeance, or does he turn aside, to help a child as helpless as he once was himself?