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Doctor Ferdinand Peeters
The story of doctor Ferdinand Peeters (1918-1998) and his role in the development of the pill has held Belgium in thrall for almost a decade. It is time to introduce the real father of the contraceptive pill to the rest of the world. After years of research, Belgian journalist Karl van den Broeck concluded that not the American Gregory Pincus was the inventor of the pill. His prototype had so many adverse effects that it wasn’t a viable option in the long term. It was the Belgian doctor Ferdinand Peeters who, in 1959-1960, created the first clinically applicable contraceptive pill: Anovlar. It was this pill that set the standard for all future pills to follow. Ferdinand – Nand – Peeter...
Neuroendocrine Tumours
This book is a timely textbook that covers all aspects of neuroendocrine tumors (NET) from epidemiology, pathological classification and evaluation and molecular biology through to diagnostic imaging methods and therapeutic options, including the latest targeted therapies. The various types of NET are individually discussed, including carcinoid tumors, insulinomas, gastrinomas, glucagonomas, VIPomas, somatostatinomas, PPomas, medullary thyroid carcinomas, adrenocortical cancer, pheochromocytomas, paragangliomas and non-functioning pancreatic NETs. The contributing authors are internationally recognized experts who bring a wealth of experience to the subject. This book will be an invaluable source of information for practicing medical oncologists, surgeons, endocrinologists, gastroenterologists and pathologists and also trainees.
Organizations
to do to ensure survival, and (2) principles for designing organizational structures in such a way that they can realize the required functions adequately. In the course of their elaboration, we will show that these principles are general – i.e., that they hold for all organizations. 1.5 Conceptual Background To describe organizations as social systems conducting experiments and to present principles for designing an infrastructure supporting the “social experiment,” we use concepts from (organizational) cybernetics, social systems theory, and Aristotle’s ethics. In this book, we hope to show that concepts from these traditions – as introduced by their relevant representatives – ...
Targeted Therapies for Solid Tumors
This volume provides readers a comprehensive and state-of-the-art overview about the range of applications of targeted therapies for solid tumors. The sections of the book have been structured to review the oncogene addicted tumors, the pharmacology and clinical development of new molecularly targeted agents, the use of biomarkers as prognostic, predictive and surrogate endpoints, and the evaluation of tumor response and specific malignancies treated with targeted agents. The book also covers some of the newest developments in cancer therapy that are not adequately covered by any current available literature. Written by recognized experts in the field, Targeted Therapies for Solid Tumors: A Handbook for Moving Toward New Frontiers in Cancer Treatment provides a unique and valuable resource in the field of molecular oncology, both for those currently in training, and for those already in clinical or research practice.
Column Generation
Column Generation is an insightful overview of the state of the art in integer programming column generation and its many applications. The volume begins with "A Primer in Column Generation" which outlines the theory and ideas necessary to solve large-scale practical problems, illustrated with a variety of examples. Other chapters follow this introduction on "Shortest Path Problems with Resource Constraints," "Vehicle Routing Problem with Time Window," "Branch-and-Price Heuristics," "Cutting Stock Problems," each dealing with methodological aspects of the field. Three chapters deal with transportation applications: "Large-scale Models in the Airline Industry," "Robust Inventory Ship Routing ...
Biomarker
Clinicians, scientists, and health care professionals use biomarkers or biological markers as a measure of a person’s present health condition or response to interventions. An ideal -biomarker should have the following criteria: (I) ability to detect fundamental features of the disease, (II) ability to differentiate from other closely related diseases, (III) ability to detect early stages and stages of progression, (IV) the method should be highly reliable, easy to perform and inexpensive, and (V) sample sources should be easily accessible from body. Most of the chapters in this book follow the basic principle of biomarkers.
Handbooks in Operations Research and Management Science: Transportation
This book contains eleven chapters describing some of the most recent methodological operations research developments in transportation. It is structured around the main transportation modes, and each chapter is written by a group of well-recognized researchers. Because of the major impact of operations research methods in the field of air transportation over the past forty years, it is befitting to open the book with a chapter on airline operations management. This book will prove useful to researchers, students, and practitioners in transportation and will stimulate further research in this rich and fascinating area. - Volume 14 examines transport and its relationship with operations and management science - 11 chapters cover the most recent research developments in transportation - Focuses on main transportation modes-air travel, automobile, public transit, maritime transport, and more
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