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The population structure in the world is rapidly changing, to the extent that in 75 years we will face a tripling of the elderly population. Although women are favored in terms of life expectancy, they also live with a longer period of disability (approximately twice that of aging men), as well as with the enemies of all the elderly, cardiovascular disease, cancer, and dementia. Menopause is the endocrine event that overlaps with aging, potentially worsening both the quality of life and the risks of disease in women.While the effect of hormone replacement therapy (HRT) on menopausal symptoms is generally viewed as rapid and consistent, and is thereby accepted by the scientific community, its relationship to the other aforementioned chronic conditions associated with menopause is considered variable and controversial.In analyzing these complex issues, this volume yields new and significant insights into both the study of menopause-related disorders and their treatment, by illustrating the most recent information on mechanisms of actions of new estrogen receptors and on the use of sophisticated techniques of statistical analysis for population-based studies.
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L’osteoporosi è una complessa condizione patologica che può presentarsi in tutte le fasce di età, alla cui insorgenza concorrono molteplici fattori. Ne deriva pertanto la necessità di una rigorosa conoscenza eziopatogenetica fondamentale, oltre che clinica e diagnostica. Le conoscenze sempre più avanzate nel campo del metabolismo osseo, della clinica e farmacologia, hanno condizionato e reso necessario un adeguamento tecnico da parte dei medici specialisti ed in particolare del radiologo, in passato focalizzato sul solo aspetto diagnostico e oggi sempre più proiettato verso nuove prospettive di studio. L’opera si articola in sei parti distinte: dalla biologia, istologia e fisiopato...
This volume investigates the area of steroid actions in hormone-dependent cancer. Subjects covered: include molecular biology of steroid expression; oncogenes and tumour suppressor genes; steroid content and metabolism in breast tumours; regulation of cancer cell growth by hormones and anti-hormones; stromal-epithelial interactions in vitro; endocrine-related tumours (breast and prostate cancer); new specific enzyme inhibitors in the management of human cancer; mechanism of action of pure anti-hormones; selected oncogene products in cancer prognosis; clinical trials of breast and prostate cancer; and diet prevention and chemoprevention of main human tumours.
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