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An Introduction to Cardiac Electrophysiology
Knowledge of the basic mechanisms of cardiac excitation is a prerequisite to the understanding of cardiac arrythmias and their response to therapy. The goal of this book is to provide readers unacquainted with the matter with the information necessary to develop pathophysiologically oriented clinical reasoning in this area. Besides covering normal
Theory of Heart
In recent years there has been a growth in interest in studying the heart from the perspective of the physical sciences: mechanics, fluid flow, electromechanics. This volume is the result of a workshop held in July 1989 at the Institute for Nonlinear Sciences at the University of California at San Diego that brought together scientists and clinicians with graduate students and postdoctoral fellows who shared an interest in the heart. The chapters were prepared by the invited speakers as didactic reviews of their subjects but also include the structure, mechanical properties, and function of the heart and the myocardium, electrical activity of the heart and myocardium, and mathematical models of heart function.
Connexins
Connexins: A Guide is a practical and valuable reference and text covering a wide scope of information about the connexin family of membrane channel proteins. The editors and contributing authors intend for this cutting-edge work to be informative to scientists wishing to learn about the field, as well as to those who are active researchers in this area. Connexins: A Guide masterfully addresses specific needs of the scientific community; it is a comprehensive and comprehensible narrative of the uncommonly diverse connexin field, making previously hard-to-find information easily accessible, while also presenting intelligible insights into the extensive experimental methods and conceptual frameworks necessary to appreciate and understand the important roles that connexin channel proteins play in health and disease.
Cardiac Electrophysiology: from Cell to Bedside
Cardiac Electrophysiology: From Cell to Bedside puts the latest knowledge in this subspecialty at your fingertips, giving you a well-rounded, expert grasp of every cardiac electrophysiology issue that affects your patient management. Drs. Zipes, Jalife, and a host of other world leaders in cardiac electrophysiology use a comprehensive, multidisciplinary approach to guide you through all of the most recent cardiac drugs, techniques, and technologies. Get well-rounded, expert views of every cardiac electrophysiology issue that affects your patient management from preeminent authorities in cardiology, physiology, pharmacology, pediatrics, biophysics, pathology, cardiothoracic surgery, and biome...
Gap Junctions: Molecular Basis of Cell Communication in Health and Disease
Since the first gap junction protein (connexin) was cloned over a decade ago, more than a dozen connexin genes have been cloned. Consequently, a wealth of information on the molecular basis of gap junctional communication has been accumulated. This book pays tribute to this exciting era in the history of cell communication research by documenting the great strides made in this field as a result of the merging of biophysics and molecular biology, two of the most powerful approaches to studying the molecular basis of membrane channel behavior. Twenty-eight comprehensive chapters, authored by internationally recognized leaders in the field, discuss the biophysical, physiological, and molecular ...
Gap Junction-Mediated Intercellular Signalling in Health and Disease
Gap junctions are key elements in communication between cells in multicellular organisms. It is clear that their activity is essential for normal embryonic development and normal function in adult organs, although the individual roles of the proteins that form the channels (connexins) are not yet fully understood. The last few years have seen considerable progress in this field and exciting new issues concerning gap junctional intercellular communication are being raised. Perturbed gap junction activity is beginning to be linked to certain pathologies, e.g. mutations in the major connexin of the heart have been found in human patients suffering from visceroatrial heterotaxia syndrome and mut...
Neuroscience in the 21st Century
Edited and authored by a wealth of international experts in neuroscience and related disciplines, this key new resource aims to offer medical students and graduate researchers around the world a comprehensive introduction and overview of modern neuroscience. Neuroscience research is certain to prove a vital element in combating mental illness in its various incarnations, a strategic battleground in the future of medicine, as the prevalence of mental disorders is becoming better understood each year. Hundreds of millions of people worldwide are affected by mental, behavioral, neurological and substance use disorders. The World Health Organization estimated in 2002 that 154 million people glob...
Current Concepts in Arrhythmogenic Cardiomyopathy, Second Edition
Current Concepts in Arrhythmogenic Cardiomyopathy, Second Edition presents essential insights into all aspects of this complex disease and will serve as a valuable guide to help readers provide the best possible care for their patients. Discussion by internationally recognized authorities includes: -Increasing evidence that arrhythmogenic cardiomyopathy is not necessarily confined to the RV, but often involves both ventricles -Basic and clinical science of arrhythmogenic cardiomyopathy -Pathophysiology, molecular mechanisms, and genetic background -The mechanisms of disease progression leading to a diversity of disease phenotypes -Guidance in the clinical setting for diagnosis, risk strati fication, and therapy
Gap Junctions
This monograph contains research articles from the leading laboratories around the world on gap junctions, the intercellular channels that allow communication between neighbouring cells. It describes the latest results in gap junctions research, the structural and functional characterization of cell-cell channels, the assembly and degradation of gap junctions, the expression and function of gap junctions in different tissues, knockout studies of gap junction genes, the regulation of connexin gene expression, and the functions of gap junctions in development and cancer. Any laboratory interested in intercellular communications and gap junction research will find this monograph an indispensable source of information and reference.
