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Thymic Stromal Alterations and Genetic Disorders of Immune System
The pathogenic mechanisms underlying primary T-cell disorders are mainly related to molecular alterations of genes whose expression is intrinsic to hematopoietic cells. However, since the differentiation process requires a crosstalk among thymocytes and the thymic microenvironment, molecular alterations of genes, involved in the differentiation and functionality of the stromal component of the thymus, may lead to a severe T-cell defect or failure of central tolerance, as well. The first example of severe combined immunodeficiency (SCID) not related to an intrinsic alteration of the hematopoietic cell but rather of the thymic epithelial component is the Nude/SCID phenotype, inherited as an au...
Cross Talk between Lymph Node Lymphatic Endothelial Cells and T Cells in Inflammation and Cancer
Lymphocytes constantly survey the lymph nodes in search for potential infection by a pathogen. They enter the afferent lymphatic vessel that serves as a conduit to transport the motile lymphocytes to the draining lymph node. Lymphatic vessels (LVs) are present in most vascularized tissues. They are traditionally regarded as passive conduits for soluble antigens and leukocytes. Afferent LVs begin as blind ended capillaries, which give rise to collecting vessels that merge and connect with draining lymph nodes (dLNs). Initial lymphatic capillaries are composed of Lymphatic Endothelial Cells (LECs) connected by discontinuous cell junctions, which join to form larger collecting lymphatic vessels...
Mark Lane Express
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The Girl on the Magazine Cover
From the Gibson Girl to the flapper, from the vamp to the New Woman, Carolyn Kitch traces mass media images of women to their historical roots on magazine covers, unveiling the origins of gender stereotypes in early-twentieth-century American culture.
The Madness of Grief
The #2 SUNDAY TIMES BESTSELLER from the author of MURDER BEFORE EVENSONG 'Immensely moving and disarmingly witty' Nigella Lawson 'Such a moving, tough, funny, raw, honest read' Matt Haig 'Beautifully written, moving and gut-wrenching, but also at times very funny' Ian Rankin 'Captures brilliantly, beautifully, bravely the comedy as well as the tragedy of bereavement' The Times 'Will strike a chord with anyone who has grieved' Independent When the Reverend Richard Coles's partner died suddenly, shortly before Christmas in 2019, what came next took Richard by surprise. Despite his years of experience assisting his parishioners in examining life's moral questions, Richard now found he needed guidance himself. Much about grief was unexpected: the volume of 'sadmin' that must be undertaken, how much harder it is travelling solo for work, the pain of typing a text message to your partner - then remembering they are gone. This deeply personal account of life after grief will resonate, unforgettably, long after the final page has been turned.
