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Genetics Meets Metabolomics
This book is written by leading researchers in the fields about the intersection of genetics and metabolomics which can lead to more comprehensive studies of inborn variation of metabolism.
The Mouse in Biomedical Research
History, Wild Mice, and Genetics, the first volume in the four volume set, The Mouse in Biomedical Research, provides information about the history, biology and genomics of the laboratory mouse (Mus musculus), as well as basic information on maintenance and use of mouse stocks. Mouse origins and relationships are covered in chapters on history, evolutionary taxonomy and wild mice. Genetics and genomics of the mouse are covered in chapters on genetic nomenclature, gene mapping, cytogenetics and the molecular organization of the mouse genome. Maintenance of laboratory mice is described in chapters on breeding systems for various types of strains and stocks and genetic monitoring. Use of the mouse as a model system for basic biomedical research is described in chapters on chemical mutagenesis, gene trapping, pharmacogenetics and embryo manipulation. The information in Volume 1 serves as a primer for scientists new to the field of mouse research.
Beyond Our Genes
The genotype/phenotype dichotomy is being slowly replaced by a more complex relationship whereby the majority of phenotypes arise from interactions between one’s genotype and the environment in which one lives. Interestingly, it seems that not only our lives, but also our ancestors’ lives, determine how we look. This newly recognized form of inheritance is known as (epi)genetic, as it involves an additional layer of information on top of the one encoded by the genes. Its discovery has constituted one of the biggest paradigm shifts in biology in recent years. Understanding epigenetic factors may help explain the pathogenesis of several complex human diseases (such as diabetes, obesity and cancer) and provide alternative paths for disease prevention, management and therapy. This book introduces the reader to the importance of the environment for our own health and the health of our descendants, sheds light on the current knowledge on epigenetic inheritance and opens a window to future developments in the field.
Transgenic Mouse Methods and Protocols
Marten Hofker and Jan van Deursen have assembled a multidisciplinary collection of readily reproducible methods for working with mice, and particularlyfor generating mouse models that will enable us to better understand gene function. Described in step-by-step detail by highly experienced investigators, these proven techniques include new methods for conditional, induced knockout, and transgenic mice, as well as for working with mice in such important research areas as immunology, cancer, and atherosclerosis. Such alternative strategies as random mutagenesis and viral gene transduction for studying gene function in the mouse are also presented.
The UFAW Handbook on the Care and Management of Laboratory and Other Research Animals
The seminal reference on the care of laboratory and captiveanimals, The UFAW Handbook on the Care and Management ofLaboratory and Other Research Animals is a must-have for anyoneworking in this field. The UFAW Handbook has been thedefinitive text since 1947. Written for an international audience,it contains contributions from experts from around the world. The book focuses on best practice principles throughout, providingcomprehensive coverage, with all chapters being peer reviewed byanonymous referees. As well as addressing the husbandry oflaboratory animals, the content is also of great value to zoos andaquaria. Changes for the eighth edition: Revised and updated to reflect developments si...
Entangled Life
This volume explores the interactions between organisms and their environments and how this “entanglement” is a fundamental aspect of all life. It brings together the work and ideas of historians, philosophers, biologists, and social scientists, uniting a range of new perspectives, methods, and frameworks for examining and understanding the ways that organisms and environments interact. The volume is organized into three main sections: historical perspectives, contested models, and emerging frameworks. The first section explores the origins of the modern idea of organism-environment interaction in the mid-nineteenth century and its development by later psychologists and anthropologists. ...
Current Topics in Developmental Biology
This Series provides a comprehensive survey of the major topics in the field of developmental biology. The volumes are valuable to researchers in animal and plant development, as well as to students and professionals who want an introduction to cellular and molecular mechanisms of development. The Series has recently passed its 30-year mark, making it the longest-running forum for contemporary issues in developmental biology.
The Nature of Life and Its Potential to Survive
This book looks at the persistence of life and how difficult it would be to annihilate life, especially a species as successful as humanity. The idea that life in general is fragile is challenged by the hardiness of microbes, which shows that astrobiology on exoplanets and other satellites must be robust and plentiful. Microbes have adapted to virtually every niche on the planet, from the deep, hot biosphere, to the frigid heights of the upper troposphere. Life, it seems, is almost indestructible. The chapters in this work examine the various scenarios that might lead to the extermination of life, and why they will almost always fail. Life's highly adaptive nature ensures that it will cling on no matter how difficult the circumstances. Scientists are increasingly probing and questioning life's true limits in, on and above the Earth, and how these limits could be pushed elsewhere in the universe. This investigation puts life in its true astronomical context, with the reader taken on a journey to illustrate life's potential and perseverance.
Literature-based Discovery
This is the first coherent book on literature-based discovery (LBD). LBD is an inherently multi-disciplinary enterprise. The aim of this volume is to plant a flag in the ground and inspire new researchers to the LBD challenge.
Morphological Mouse Phenotyping
Morphological Mouse Phenotyping: Anatomy, Histology and Imaging is an atlas of explanatory diagrams and text that guides the reader through normal mouse anatomy, histology, and imaging. The book is targeted for mouse researchers and veterinarian and human pathologists, and presents a complete, integrative description of normal mouse morphology. Disease animal models are fundamental in research to improve human health. The success of using genetically engineered mice to evaluate molecular disease hypotheses has encouraged the development of massive global projects, making the mouse the most used animal disease model. Laboratory mouse populations are straining the housing capacity of pharmaceu...
