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Emerging Learnings in Cell Therapy: Novel Binding Domains, Universal CAR-T Cells, and More
The Past decade has seen significant advances in cancer immunotherapy with the development of multiple strategies including monoclonal antibodies targeting checkpoint blockers, oncolytic viruses, fusion proteins and cell therapies such as tumor-specific chimeric antigen receptor (CAR-) T cell therapy, NK cell therapy and γδ-T-cell therapy. Multiple cell therapies including sipuleucel-T (Provange), axicabtagene ciloleucel (Yescarta), brexucabtagene autoleucel (Tecartus), tisagenlecleucel (Kymriah), lisocabtagene maraleucel (Breyanzi), idecabtagene vicleucel (Abecma) and ciltacabtagene autoleucel (Carvykti) have been approved by the US FDA for different hematological cancers and hormone-refractory prostate cancer (Provange). Impressive results were noted with CAR-T cell therapy with objective response rates (ORR) as high as 100% in certain hematological cancers and with responses durable over 10 years in some patients.
Muiwlanej kikamaqki "Honouring Our Ancestors"
Drawing upon oral and documentary evidence, this volume explores the lives of noteworthy Mi’kmaw individuals whose thoughts, actions, and aspirations impacted the history of the Northeast but whose activities were too often relegated to the shadows of history. The book highlights Mi’kmaw leaders who played major roles in guiding the history of the region between 1680 and 1980. It sheds light on their community and emigration policies, organizational and negotiating skills, diplomatic endeavours, and stewardship of land and resources. Contributors to the volume range from seasoned scholars with years of research in the field to Mi’kmaw students whose interest in their history will prove...
The Molecular Basis of Cancer
Successfully fighting cancer starts with understanding how it begins. This thoroughly revised 3rd Edition explores the scientific basis for our current understanding of malignant transformation and the pathogenesis and treatment of cancer. A team of leading experts thoroughly explain the molecular biologic principles that underlie the diagnostic tests and therapeutic interventions now being used in clinical trials and practice. Incorporating cutting-edge advances and the newest research, the book provides thorough descriptions of everything from molecular abnormalities in common cancers to new approaches for cancer therapy. Features sweeping updates throughout, including molecular targets for the development of anti-cancer drugs, gene therapy, and vaccines...keeping you on the cutting edge of your specialty. Offers a new, more user-friendly full-color format so the information that you need is easier to find. Presents abundant figures-all redrawn in full color-illustrating major concepts for easier comprehension. Features numerous descriptions of the latest clinical strategies-helping you to understand and take advantage of today’s state-of-the-art biotechnology advances.
Upper Tract Urothelial Carcinoma
Upper Tract Urothelial Carcinoma represents the first book of its kind to be dedicated solely to UTUC. It's aim is to improve understanding and eventually care of a disease that is greatly understudied and underappreciated, yet commonly dealt with by many medical and urologic oncologists. The volume features new data regarding genetic susceptibility, gene expression studies and causative factors; contemporary concepts and controversies regarding diagnosis and staging of UTUC; prediction tools and their value in treatment decisions within each disease stage and patient selection and treatment options such as endoscopic management, distal ureterectomy, radical nephroureterectomy and chemotherapy. Up-to-date information regarding boundaries of surgical resection, indication and extent of lymphadenectomy is covered as well as the role of perioperative/neoadjuvant chemotherapy in patients with high-risk UTUC. Upper Tract Urothelial Carcinoma will be of great value to all Urologists, Medical Oncologists and fellows in Urologic Oncology as well as upper level residents in training in Urology and Medical Oncology.
The Authentic Swing
The Story Behind THE LEGEND OF BAGGER VANCE If you've read his books THE WAR OF ART and TURNING PRO, you know that for thirty years Steven Pressfield (GATES OF FIRE, THE AFGHAN CAMPAIGN etc.) wrote spec novel after spec novel before any publisher took him seriously. How did he finally break through? Ignoring just about every rule of commercial book publishing, Pressfield's "first" novel not only became a major bestseller (over 250,000 copies sold), it was adapted into a feature film directed by Robert Redford and starring Matt Damon, Will Smith, and Charlize Theron. Where did he get the idea? What magical something did THE LEGEND OF BAGGER VANCE have that his previous manuscripts lacked? Why did Pressfield decide to write a novel when he already had a well established screenwriting career? How does writing a publishable novel really work? Taking a page from John Steinbeck's classic JOURNAL OF A NOVEL, Steven Pressfield offers answers for these and scores of other practical writing questions in THE AUTHENTIC SWING.
The Smell of War
Roland Bartetzko is a former soldier with the German Army, the Kosovo Liberation Army, and Croatian Defense Council and took part in extensive engagements during the conflicts in the Balkans. These are his memories of dangerous, deadly, and sometimes funny times. It is the true story of what the war was like in Bosnia and in Kosovo. Combined with the stories are his 'observations' about the military tactics that were applied in these conflicts. They provide practical advice for soldiers and civilians on how to survive in a war zone.
Quantitative Security Risk Assessment of Enterprise Networks
Protection of enterprise networks from malicious intrusions is critical to the economy and security of our nation. This article gives an overview of the techniques and challenges for security risk analysis of enterprise networks. A standard model for security analysis will enable us to answer questions such as “are we more secure than yesterday” or “how does the security of one network configuration compare with another one”. In this article, we will present a methodology for quantitative security risk analysis that is based on the model of attack graphs and the Common Vulnerability Scoring System (CVSS). Our techniques analyze all attack paths through a network, for an attacker to reach certain goal(s).
The Secret History of Star Wars
In this thorough account of one of cinema's most lasting works, Kaminski presents the true history of how "Star Wars" was written. For this unauthorized account, he has pored through more than 400 sources.
