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DNA-Pharmaceuticals
With its focus on a completely novel class of pharmaceuticals, this book collates the hitherto scarce literature about DNA drug formulation keenly desired by biotechnologists, molecular biologists and pharmacists, as well as those working in the biotechnological and pharmaceutical industries. As such, this volume presents a wide range of gene delivery systems needed for different therapeutic applications. It fills the gap between research and clinical trials and describes pharmaceutical fundamentals for the development of efficient DNA pharmaceuticals.
ImmunoPhysics and ImmunoEngineering
ImmunoPhysics (ImmPhys) and ImmunoEngineering (ImmPhysEng), are two cross-disciplinary fields. ImmPhysEng aims to unravel quantitatively the immune-system function and regulation in health and disease. Whereas ImmPhys study and assess the physical basis of the immune response, ImmEng pursues its control and prediction. Ultimately, the overarching goal of these disciplines is to facilitate the development of therapeutic interventions to more precisely modulate and control the compromised immune response during diseases. Lately, these disciplines are becoming more popular and as such, the number of publications applying physical or engineering tools to understand the immune response is increasing. Nevertheless, there is still no scientific forum compiling the ImmPhysEng research breakthroughs. Possibly the biggest burden is to stimulate a fluent communication and syntony between a physicist or engineer and an immunologist.
Gene Vaccines
The induction of antigen-specific immune responses after in vivo transfection with expression plasmids has triggered a revolution of vaccine research. After a first hype, evoked by the fascinating options of this method, clinical studies did not reach the ambitious aims and a phase of disillusion ensued. It became obvious that Gene vaccines displayed a weaker immunogenicity in humans than had been observed in the mouse models. Meanwhile these hurdles have been overcome and gene vaccines undergo a renaissance. The present book gives an update of the “world of naked gene vaccines”, namely DNA and RNA vaccines. Its content ranges from general mechanisms, inherent immunostimulatory properties and the vast potential to modulate immune responses, to recent successful clinical studies and approved veterinary gene vaccines. Beyond the state-of-the-art of genetic immunization, the reader will be stimulated with a chapter addressing “burning questions”.
Engineering Interactive Systems 2008
Engineering Interactive Systems (EIS) 2008 was an international event combining the 2nd working conference on Human-Centred Software Engineering (HCSE 2008) and the 7th International Workshop on TAsk MOdels and DIAgrams (TAMODIA 2008). HCSE is a working conference that brings together researchers and practitioners - terested in strengthening the scientific foundations of user interface design and examining the relationship between software engineering and human-computer interaction and how to strengthen user-centred design as an essential part of so- ware engineering processes. As a working conference, substantial time is devoted to the open and lively discussion of papers. TAMODIA is an international workshop on models, such as task models and visual representations in Human-Computer Interaction (one of the most widely used notations in this area, ConcurTaskTrees, was developed in the town that hosted this year’s event). It focuses on notations used to describe user tasks ranging from textual and graphical forms to interactive, multimodal and multimedia tools.
Germany and the Holy Roman Empire
In the first single-author account of German history from the Reformation to the early nineteenth century since Hajo Holborn's study written in the 1950s, Dr Whaley provides a full account of the history of the Holy Roman Empire. Volume I extends from From Maximilian I to the Peace of Westphalia.
Science
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Fast Forward
Are you a founder searching for customers to grow your B2B startup? Fast Forward will help you find, win, and keep customers. This detailed guide on B2B sales tells you how to grow your revenue from zero to 1 million, 10 million and 100 million. The authors share more than 40 years of successful operating experience as startup founder, senior executive, board member, mentor, and investor in startups. Fast Forward outlines their insider’s perspective on market segmentation, pricing, contract negotiation, sales process, customer conversations, pipeline management, reporting, sales organization, and customer success. Fast Forward also features exclusive advice from more than 30 top-tier B2B s...
"Der neue Mensch"
Jenseits der Vereinskultur von Sport und Turnen und in Folge des gewachsenen Interesses am Körper, seiner Formung und seiner Sinnstiftung formierte sich seit dem Kaiserreich eine machtvolle - bislang in dieser Gesamtheit noch nicht in das Blickfeld der Forschung gerückte - Körperkulturbewegung, die im Umfeld von Lebensreform, Reformpädagogik, Jugendbewegung, Neureligion und Esoterik beheimatet war, und die einen nachhaltigen kulturellen Einfluß auf das zeitgenössische Körperverständnis ausübte. Im Mittelpunkt der Göttinger Habilitationsschrift steht die Analyse der Praktiken und Theorien der z.T. kommerziell orientierten, z.T. im kulturellen Untergrund agierenden Bewegung vom spät...
Model Driven Architecture
Model-Driven Architecture (MDA) is an initiative proposedby the Object M- agement Group (OMG) for platform-generic software development. MDA s- arates the speci?cation of system functionality from the implementation on a speci?c platform. It is aimed at making software assets more resilient to changes caused by emerging technologies. While stressing the importance of modeling, the MDA initiative covers a wide spectrum of research areas. Further e?orts are required to bring them into a coherent approach based on open standards and supported by matured tools and techniques. Thisvolumecontainstheselectedpapersoftwoworkshopson“Model-Driven Architecture – Foundations and Applications” (MDAF...
