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Serotonin
Serotonin - A Chemical Messenger Between All Types of Living Cells is a very interesting book on the most ancient neurotransmitter, hormone and trophic factor serotonin or 5-hydroxytryptamine (5-HT). This unique chemical is present in all living cells including plants and animals. This book will take us through a serene journey of the evolutionary history of serotonin and its role from man to mollusk. There are many interesting chapters incorporated in this book, including novel approaches for detecting minor metabolites of serotonin in human plasma, production and function of serotonin in cardiac cells, immuno-thrombotic effects of serotonin in platelets to the identification and localization of serotonin in the nervous system and gonad of bivalve mollusks.
Elevated Platelet-leukocyte Complexes are Associated With, But Dispensable for Myocardial Ischemia-reperfusion Injury
Abstract: Aims P-selectin is an activatable adhesion molecule on platelets promoting platelet aggregation, and platelet-leukocyte complex (PLC) formation. Increased numbers of PLC are circulating in the blood of patients shortly after acute myocardial infarction and predict adverse outcomes. These correlations led to speculations about whether PLC may represent novel therapeutic targets. We therefore set out to elucidate the pathomechanistic relevance of PLC in myocardial ischemia and reperfusion injury. Methods and results By generating P-selectin deficient bone marrow chimeric mice, the post-myocardial infarction surge in PLC numbers in blood was prevented. Yet, intravital microscopy, flow...
A Ligand-specific Blockade of the Integrin Mac-1 Selectively Targets Pathologic Inflammation While Maintaining Protective Host-defense
Abstract: Integrin-based therapeutics have garnered considerable interest in the medical treatment of inflammation. Integrins mediate the fast recruitment of monocytes and neutrophils to the site of inflammation, but are also required for host defense, limiting their therapeutic use. Here, we report a novel monoclonal antibody, anti-M7, that specifically blocks the interaction of the integrin Mac-1 with its pro-inflammatory ligand CD40L, while not interfering with alternative ligands. Anti-M7 selectively reduces leukocyte recruitment in vitro and in vivo. In contrast, conventional anti-Mac-1 therapy is not specific and blocks a broad repertoire of integrin functionality, inhibits phagocytosis, promotes apoptosis, and fuels a cytokine storm in vivo. Whereas conventional anti-integrin therapy potentiates bacterial sepsis, bacteremia, and mortality, a ligand-specific intervention with anti-M7 is protective. These findings deepen our understanding of ligand-specific integrin functions and open a path for a new field of ligand-targeted anti-integrin therapy to prevent inflammatory conditions
Sustainable Practices in the Textile Industry
The increasing environmental and health concerns owing to the use of large quantities of water and hazardous chemicals in conventional textile finishing processes has lead to the design and development of new dyeing strategies and technologies. Sustainable Practices in the Textile Industry comprises 13 chapters from various research areas dealing with the application of different sustainable technologies for enhancing the dyeing and comfort properties of textile materials with substantial reduction in wastewater problems. Chapters focus on the sophisticated methods for improving dye extraction and dyeing properties which will minimize the use of bioresource products. This book also brings out the innovative ways of wet chemical processing to alleviate the environmental impacts arising from this sector. This book also discusses innovations in eco-friendly methods for textile wet processes and applications of enzymes in textiles in addition to the advancements in the use of nanotechnology for wastewater remediation.
The Magnificent Max Baer
Boxing might not have survived the 1930s if not for Max Baer. A contender for every heavyweight championship 1932-1941, California's "Glamour Boy" brought back the "million-dollar gate" not seen since the 1920s. His radio voice sold millions of Gillette razor blades; his leading-man appeal made him a heartthrob in The Prizefighter and the Lady (1933). The film was banned in Nazi Germany--Baer had worn a Star of David on his trunks when he TKOed German former champ Max Schmeling. Baer defeated 275-pound Primo Carnera in 1934 for the championship, losing it to Jim Braddock the next year. Contrary to Cinderella Man, (2005), Baer--favored 10 to 1--was not a villain and the fight was more controversial than the film suggested. His battle with Joe Louis three months later drew the highest gate of the decade. This first comprehensive biography covers Baer's complete ring record, his early life, his career on radio, film, stage and television, and his World War II army service.
