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Researchers in structural genomics continue to search for biochemical and cellular functions of proteins as well as the ways in which proteins assemble into functional pathways and networks using either experimental or computational approaches. Based on the experience of leading international experts, Structural Genomics and High Throughput Stru
- Provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology - Contributions from leaders in their fields - Abundant references
This up-to-date sourcebook covers viral and bacterial superantigens (SAgs) from molecular structure and immunological processes to pathology and treatment of superantigen-mediated human diseases. Discusses diseases beyond Toxic Shock Syndrome, such as autoimmune and inflammatory skin conditions, as well as the role of superantigens in other infectious diseases. Illustrated with molecular structures of superantigens.
Computer-aided drug design and in silico screening have contributed to the discovery of several compounds that have either reached the market or entered clinical trials. In silico Lead Discovery is a compilation of the efforts of several experts on bioinf
Four-wheel-drive was authorised in rallying from 1979, but for a time no serious car manufacturer even tried to harness it to their cars. Soon, though, it was Audi who produced the world’s first rally-winning four-wheel-drive car – the Quattro, although it was Peugeot which designed, developed, campaigned and won with the first truly sophisticated four-wheel-drive Group B Car – the 205 Turbo 16; the first truly great, purpose-designed Group B car. Determined to win at almost any cost, Peugeot hired Jean Todt (who would later transform the fortunes of the Ferrari F1 organisation) in 1981, and set him an ambitious target: his dream car had to be running in 1983, homologated in 1984, and capable of winning World Championships by 1985. Packed with illustrations, technical details, facts, figures and successes of this innovative car, this exciting book is a must for any rally fan.
The modern drug developers? guide for making informed choices among the diverse target identification methods Target Discovery and Validation: Methods and Strategies for Drug Discovery offers a hands-on review of the modern technologies for drug target identification and validation. With contributions from noted industry and academic experts, the book addresses the most recent chemical, biological, and computational methods. Additionally, the book highlights techologies that are applicable to ?difficult? targets and drugs directed at multiple targets, including chemoproteomics, activity-based protein profiling, pathway mapping, genome-wide association studies, and array-based profiling. Thro...
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Provides the reader with an in-depth sociocultural understanding of Chinese negotiating behaviours and tactics in Sino-Western business negotiation context. It presents fresh approaches, coherent frameworks, and 40 reader-friendly cases.