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Contemporary Issues in Modeling Psychopathology
Despite considerable progress in clinical and basic neurosciences, the cure of psychiatric disorders is still remote, little is known about their prevention, and the etiology and molecular mechanisms of mental disorders are still obscure. Diagnoses are still guided by patients' stories. The mission of animal models is to bridge the gap between `the story and the synapse.' Contemporary Issues in Modeling of Psychopathology attempts to do this by examining such questions as `What good might come from such a model? Are we wasting our time? How far can we carry results from model animals, such as rats and mice, without causing a highly distorted view of the field and its goals?' This book serves as the opening volume for a new series, Neurobiological Foundation of Aberrant Behaviors.
Anxiety and Anxiolytic Drugs
The present volume gives a comprehensive overview on the current state of basic and clinical research on Anxiety and Anxiolytic Drugs. Using newly developed methods and techniques researchers are now beginning to understand the molecular mechanisms of anxiety, anxiety disorders and their treatment. In parallel, new drug targets have been generated and the first clinical studies with new compounds have been started. In 20 chapters written by numerous experts in the field comprehensive information on all relevant topics is provided.
Cytokines, Stress, and Depression
Cytokines had been characterized in the early eighties as communication mole cules between immune cells, and between immunocytes and other peripheral cells, such as fibroblasts and endothelial cells. They play a key role in the regulation of the immune response and the coordination of the host response to infection. Based on these biological properties, nobody would have predicted that one decade later cytokines would burst upon neurosciences and permeate into several avenues of current research. In neurology, the connection between cytokines and inflammation, and the demonstration of a pivotal role of some of these molecules in cell death by apoptosis, prompted the investigation of their in...
Neurobiology of Mental Illness
The new edition of this definitive textbook reflects the continuing reintegration of psychiatry into the mainstream of biomedical science. The research tools that are transforming other branches of medicine - epidemiology, genetics, molecular biology, imaging, and medicinal chemistry - are also transforming psychiatry. The field stands poised to make dramatic advances in defining disease pathogenesis, developing diagnostic methods capable of identifying specific and valid disease entities, discovering novel and more effective treatments, and ultimately preventing psychiatric disorders. The Neurobiology of Mental Illness is written by world-renowned experts in basic neuroscience and the patho...
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Działalność gospodarcza jednostek samorządu terytorialnego. Dopuszczalność i granice jej prowadzenia
W publikacji omówiono zagadnienia prowadzenia działalności gospodarczej przez jednostki samorządu terytorialnego z uwzględnieniem jej racjonalności i efektywności, a przede wszystkim w kontekście legalności, w tym dopuszczalnych form prawnoorganizacyjnych jej prowadzenia. W poszczególnych częściach książki zostały omówione zróżnicowane formy i sposoby prowadzenia działalności gospodarczej przez jednostki samorządu terytorialnego, zarówno w sferze użyteczności publicznej, jak i poza nią. Zagadnienia te były prezentowane podczas ogólnopolskiego seminarium naukowego, które zostało zorganizowane przez Katedrę Prawa Samorządu Terytorialnego Uniwersytetu Jagiellońsk...
Accelerating CNS Drug Development
There has been a remarkable increase in the number of available drugs for disorders of the CNS in recent years and there are many more novel compounds in the pipeline. But most of these compounds will be in development for many years. Although it is vital that trials are thorough, there are ways of accelerating development so that these vital drugs are available sooner. Based on evidence from real examples, this book examines options on the design of trials, and questions the need for prolonged testing in some areas. It is, therefore, an essential text for all those involved in the development of CNS drugs.
Atlas of Alberta Lakes
This compilation of data on 100 lakes in Alberta (outside the mountain areas) covers physical characteristics, water quality, wildlife, recreational opportunities and access for each lake, and includes maps, photographs, diagrams and statistical tables.
Animal Models for Examining Social Influences on Drug Addiction
Animal Models for Examining Social Influences on Drug Addiction, Volume 140 in the International Review of Neurobiology series, provides insights on social factors that mediate drug addiction. This book discusses current research and projects, with specific chapters focusing on Social Influences on Nicotine-related Behaviors in Rodents, Models of Alcohol Intake in Social Contexts, Social Factors in Ethanol Sensitization, Social Modulation of Heroin Intake, Amphetamines and Social Aspects of Addiction, Amphetamines and Social Aspects of Addiction, Social Models of Cannabis Use, Oxytocin and Rodent Models of Addiction, Social Place Preference and Reward, Social Defeat Stress, and more. - Covers the often neglected topic of social factors that mediate drug addiction and its consequences - Presents research studies using animal models of addiction that are often ignored - Aims to highlight the importance of using paradigms that incorporate social aspects into preclinical addiction studies
