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Understanding the Gut-Bone Signaling Axis
This is the first book compiling current research on the gut-bone signaling axis and its implications in the pathophysiology of GI and bone diseases. Rather than focusing on a single mechanism, this book provides the reader with a broad view on gut-bone signaling and the most up-to-date information in this rapidly growing area. The volume is also unique in that it looks at what is known about GI diseases affecting bone and then examines the role of the microbiome and its modulation by pre and probiotics to treat bone disease, placing this topic within the context of gut-bone signaling pathways. Understanding the Gut-Bone Signaling Axis will thus provide an understanding of how various therapies could be applied to this area.
RAMPs
Among the many GPCRs discovered, the calcitonin family of receptors comprise of members that regulate a number of physiological processes and are involved in many pathological conditions. Therefore, understanding how these receptors function is a critical question in the field. When Foord and his colleagues discovered that a single transmembrane protein called Receptor Activity Modifying Proteins (RAMPs) could modulate the surface expression of GPCRs of the calcitonin family, it widely opened the field of receptor life cycle. Hundreds of studies have confirmed the importance of RAMPs in the life cycle of this receptor family. Receptor biology is a rapidly expanding field and with the advances in cell and molecular biology and in vivo techniques, it is very likely that the field of RAMPs will explode further and many unanswered questions will be answered with in the next few years.
Optimizing Medicine Residency Training Programs
The medical profession requires extensive training and preparation in order to ensure the success and competency of future doctors and healthcare professionals. With an emphasis on professional development and medical education, current professionals in this field acknowledge the importance of residency programs and training in the professional development of future doctors. Optimizing Medicine Residency Training Programs presents a comprehensive overview of chapters ranging from the history of medicine to opportunities and research for further exploration geared toward the professional development and medical training for the next generation of doctors and healthcare professionals. This publication is an essential reference source for academicians, practitioners, and professionals interested in the education and training of modern medical professionals.
New Technologies for Toxicity Testing
The central theme running through this volume on New Technologies for Toxicity Testing is the development and application of advanced techniques for cell and tissue culture, as well as new markers and endpoints of toxicity, as alternatives to the traditional paradigm of relying on data from laboratory animal tests to undertake labelling and risk assessment. Of course, many of the techniques and methods described in this volume are in the early stages of development, and much work will be needed to ensure their further improvement, optimisation and validation. However, we are confident that this will be achieved and that, just as with the in vitro assays that were validated and granted regulatory acceptance over the last decade, these, and many other new, advanced methods, will likewise become part of the toxicologist’s improved toolbox for coping with increasingly stringent and numerous regulatory requirements and test chemicals, while placing less reliance on traditional testing paradigms.
Nutritional Influences on Bone Health
This book comprehensively covers the topics and discussions covered at the 10th International Symposium on Nutritional Aspects of Osteoporosis. It is the only international meeting that exclusively covers the role of nutrition on musculoskeletal health and function. Current thinking on the role of nutrition on bone and muscle development and health, and as a means of preventing osteoporosis, falls and fractures is covered. The latest evidence on the potential roles that protein, potassium, B vitamins, vitamin D, omega-3 fatty acids, and flavonoids in the context of bone and muscle health are also discussed. Nutritional Influences on Bone Health reviews the role of nutrition in bone health and its potential role in preventing osteoporosis and sarcopenia in ageing populations, providing a valuable and practically applicable resource for practising and trainee health and medical professionals.
Protein Dimerization and Oligomerization in Biology
This volume has a strong focus on homo-oligomerization, which is surprisingly common. However, protein function is so often linked to both homo- and hetero-oligomerization and many heterologous interactions likely evolved from homologous interaction, so this volume also covers many aspects of hetero-oligomerization.
